Status:
COMPLETED
Adding Exercise to Antidepressant Medication Treatment for Depression
Lead Sponsor:
University of Texas Southwestern Medical Center
Collaborating Sponsors:
National Institute of Mental Health (NIMH)
Conditions:
Depression
Eligibility:
All Genders
18-70 years
Phase:
NA
Brief Summary
This study will assess the effectiveness of an exercise program in improving antidepressant medication treatment for individuals with major depressive disorder (MDD).
Detailed Description
Partial response to antidepressant treatment is common in people with MDD and is associated with significant morbidity and reduced quality of life. Pharmacological therapies have been used to augment ...
Eligibility Criteria
Inclusion
- Diagnosis of Major Depressive Disorder
- Score of 14 or higher on the Hamilton Depression Scale (HAM-D)
- 8 to 12 weeks of SSRI treatment, with at least 6 weeks at adequate doses
- Sedentary lifestyle
- Physically capable of exercise
- Body mass index (BMI) less than 40 kg/m2
- Willing and able to comply with study requirements
Exclusion
- Significant cardiovascular disease or other medical conditions
- Uncontrolled hypertension
- Abnormal exercise stress test
- Hematologic disorders
- Comorbid disorders, including depression due to another comorbid condition, psychotic disorder, bipolar disorder, schizophrenia, schizoaffective disorder, eating disorder, or obsessive compulsive disorder (OCD)
- Alcohol and/or substance abuse in the past 6 months
- Hospitalization for mental illness within the past year
- High suicide risk
- Use of psychopharmacological or psychotherapeutic treatment other than SSRIs
- Failure to respond to two or more adequate pharmacological treatments during the current depressive episode
- Significantly elevated blood lipids
- Pregnancy
Key Trial Info
Start Date :
April 1 2003
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 1 2007
Estimated Enrollment :
126 Patients enrolled
Trial Details
Trial ID
NCT00076258
Start Date
April 1 2003
End Date
August 1 2007
Last Update
September 23 2020
Active Locations (1)
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1
University of Texas Southwestern Medical Center at Dallas
Dallas, Texas, United States, 75235