Status:
COMPLETED
Antidepressant Medication Treatment for Depression in Individuals With Chronic Heart Failure
Lead Sponsor:
Duke University
Collaborating Sponsors:
National Institute of Mental Health (NIMH)
Conditions:
Heart Failure, Congestive
Chronic Heart Failure
Eligibility:
All Genders
45+ years
Phase:
PHASE2
PHASE3
Brief Summary
This study will examine the effect of antidepressant medication on rates of death and disease in depressed people with chronic heart failure.
Detailed Description
Comorbid depression in people with chronic medical illness is a serious public health concern. Depressive disorders lead to increased morbidity, mortality, and poorer outcomes in ischemic heart diseas...
Eligibility Criteria
Inclusion
- Chronic heart failure
- Diagnostic and Statistical Manual- Fourth Edition (DSM-IV) criteria for major depression
- Current use of any antipsychotic medication at study entry
Exclusion
- Life-threatening comorbidity with a 50% or higher likelihood of death within 1 year
- History of psychoses, bipolar disorder, or severe personality disorder
- History of alcohol or drug dependence in the last year
- Severe physical disability that may interfere with the study
- Neurological impairment
- Active suicidal ideations
- Current use of antidepressant medication(s) at the start of study medication
Key Trial Info
Start Date :
November 1 2003
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 1 2008
Estimated Enrollment :
469 Patients enrolled
Trial Details
Trial ID
NCT00078286
Start Date
November 1 2003
End Date
September 1 2008
Last Update
February 27 2013
Active Locations (1)
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1
Duke Medical Center
Durham, North Carolina, United States, 27710