Status:
COMPLETED
A Phase II Study VEPEMB In Patients With Hodgkin's Lymphoma Aged ≥ 60 Years
Lead Sponsor:
Newcastle-upon-Tyne Hospitals NHS Trust
Conditions:
Lymphoma
Eligibility:
All Genders
60-120 years
Phase:
PHASE2
Brief Summary
RATIONALE: Drugs used in chemotherapy, such as vinblastine, cyclophosphamide, procarbazine, prednisolone, etoposide, mitoxantrone, and bleomycin, work in different ways to stop cancer cells from divid...
Detailed Description
OBJECTIVES: Primary * Determine the efficacy and toxicity of vinblastine, cyclophosphamide, procarbazine, prednisolone, etoposide, mitoxantrone, and bleomycin in older patients with Hodgkin's lympho...
Eligibility Criteria
Inclusion
- Inclusion criteria:
- Histologically confirmed classical Hodgkin Lymphoma (HL). No previous treatment for HL. Age ≥ 60. "Non fragile" patient (see Appendix 1) i.e. patient's mental and physical status must be sufficient to withstand the treatment described.
- No concomitant neoplasia requiring treatment or known HIV infection. Written informed consent.
- Exclusion criteria:
- Nodular lymphocyte predominance Hodgkin Lymphoma (NLPHL) Age \<60. Patient previously treated for HL. Known HIV infection or concomitant neoplasia. "Fragile patient" (see Appendix 1) or significant abnormality of another system (pulmonary, cardiac, renal, and hepatic) which is a contraindication to full dose chemotherapy.
- Unable to give informed consent.
Exclusion
Key Trial Info
Start Date :
January 1 2004
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2010
Estimated Enrollment :
175 Patients enrolled
Trial Details
Trial ID
NCT00079105
Start Date
January 1 2004
End Date
December 1 2010
Last Update
March 30 2017
Active Locations (54)
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1
Medizinische Universitaetsklinik I at the University of Cologne
Cologne, Germany, D-50924
2
Wansbeck General Hospital
Ashington, England, United Kingdom, NE63 9JJ
3
Basingstoke and North Hampshire NHS Foundation Trust
Basingstoke, England, United Kingdom, RG24 9NA
4
Royal United Hospital
Bath, England, United Kingdom, BA1 3NG