Status:
COMPLETED
Gender, Obesity, C-Reactive Protein, and Oxidative Stress
Lead Sponsor:
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Collaborating Sponsors:
University of California, Berkeley
Kaiser Permanente
Conditions:
Cardiovascular Disease
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
This randomized placebo-controlled trial will test whether supplementing with vitamins C and E can lower markers of inflammation and oxidative stress in healthy adults. We will examine whether one ant...
Detailed Description
Participants will be given 1000 mg vitamin C or 800 IU vitamin E daily for 60 days.
Eligibility Criteria
Inclusion
- Inclusion criteria:
- Nonsmoker and not passively exposed
- Males and females 18 year and older
- Able to take vitamin supplements
- Able to take acetominophen instead of aspirin or NSAIDs during the study
- Exclusion criteria:
- Pregnancy or lactation
- History of ever smoking or passive smoke exposure in the last year
- Active liver disease; history of HIV/AIDS, diabetes, kidney stones, hemochromatosis, or autoimmune diseases; heart disease, stroke, or cancer in the last 5 years
- User of prescribed anti-inflammatory or lipid-lowering medications, oral contraceptives, hormone replacement therapy, or blood-thinning drugs
- User of iron supplements or vitamin E at 600 IU per day or more
- Consumption of more than 2 alcoholic beverages per day
Exclusion
Key Trial Info
Start Date :
April 1 2004
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 24 2008
Estimated Enrollment :
396 Patients enrolled
Trial Details
Trial ID
NCT00079963
Start Date
April 1 2004
End Date
March 24 2008
Last Update
September 27 2017
Active Locations (1)
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1
University of California, Berkeley School of Public Health
Berkeley, California, United States, 94720-7360