Status:
COMPLETED
Brain Physiology in Polio Survivors
Lead Sponsor:
National Institute of Neurological Disorders and Stroke (NINDS)
Conditions:
Postpoliomyelitis
Eligibility:
All Genders
21-80 years
Brief Summary
OBJECTIVE: Many persons who survive poliomyelitis develop pain, weakness, and fatigue many decades later. It is not known why some persons develop this syndrome and others do not. One possibility is t...
Detailed Description
OBJECTIVE: Many persons who survive poliomyelitis develop pain, weakness, and fatigue many decades later. It is not known why some persons develop this syndrome and others do not. One possibility is t...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- POLIO PATIENTS:
- Complete screening evaluation.
- Meet clinical criteria for diagnosis of past polio (see below).
- Meet clinical criteria for the diagnosis of PPS (PPS group only) and have new muscle weakness.
- Age 21 or older.
- CLINICAL CRITERIA FOR PAST POLIO (CONFIRMED):
- Clinically compatible signs and symptoms of paralytic poliomyelitis (acute flaccid paralysis of one or more limbs).
- Decreased or absent tendon reflexes on the affected limbs.
- No persistent sensory or cognitive loss.
- No other apparent cause (including laboratory investigation to rule out other causes of similar syndrome).
- Neurological deficit present 60 days after onset of initial symptoms.
- Associated with isolation of either vaccine or wild poliovirus from a clinical specimen.
- CLINICAL CRITERIA FOR POST-POLIO SYNDROME:
- History of polio with partial or complete neurological and functional recovery.
- Stable function greater than 15 years.
- New onset of one or more of the following: fatigue, weakness, atrophy, muscle pain, functional loss.
- Exclusion of other explanations for the symptomatology.
- Neurological evaluation demonstrating: lower motor neuron dysfunction (confirmed by EMG, imaging studies or muscle biopsy), no sensory loss.
- Must have new onset of muscle weakness in one or more limb muscles, as determined by history and clinical examination.
- NORMAL VOLUNTEERS:
- Healthy adult volunteers ages 21-80 who are willing to participate.
- EXCLUSION CRITERIA:
- Neurological diseases or conditions, other than polio, that in the judgment of the investigators may account for the symptoms or interfere with the experimental interventions.
- Implanted devices, such as pumps, pacemakers, or metal fragments in the skull or eye.
Exclusion
Key Trial Info
Start Date :
April 6 2004
Trial Type :
OBSERVATIONAL
End Date :
December 10 2007
Estimated Enrollment :
90 Patients enrolled
Trial Details
Trial ID
NCT00080600
Start Date
April 6 2004
End Date
December 10 2007
Last Update
July 2 2017
Active Locations (2)
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1
Uniformed Services University of the Health Sciences
Bethesda, Maryland, United States, 20814
2
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States, 20892