Status:
TERMINATED
A Safety and Efficacy Study of DENSPM in Patients With Liver Cancer Who Are Not Eligible for Surgical Care
Lead Sponsor:
Genzyme, a Sanofi Company
Conditions:
Carcinoma, Hepatocellular
Eligibility:
All Genders
18+ years
Phase:
PHASE1
PHASE2
Brief Summary
Approximately 18-45 patients with Hepatocellular Carcinoma (HCC) will be treated with DENSPM at approximately 5 centers in the United States. First, we will be trying to determine the highest dose tha...
Eligibility Criteria
Inclusion
- Histologically proven HCC, or if the patient is not a medically appropriate candidate for biopsy, then all of the following criteria must be met: A.History of cirrhosis or chronic hepatitis B virus (HBV) or hepatitis C virus (HCV)infection. B.A focal liver lesion ≥ 3 cm on CT or MRI with arterial hypervascularization. C.Confirmation of the liver lesion by a second imaging modality (US/ CT/ MRI).D.AFP ≥1000 ng/ml, or ≥ 4000 ng/ml if Hepatitis B surface Ag positive.
- For recurrent HCC, radiographic evidence of progression.
- Not appropriate for curative therapy (surgical resection) or refuses potentially curative therapy
- Measurable disease, defined as having at least one measurable intrahepatic tumor lesion (using Response Criteria in Solid Tumors \[RECIST\]). Prior therapy is acceptable only if there is documented progression of the selected measurable lesion(s) following completion of the therapy.
- Required laboratory values
- Renal function: serum creatinine ≤1.2mg/dL Hematologic function: leukocyte count ≥1,500/mm3, platelet count ≥50,000/mm3 Hepatic function: transaminases ≤5x upper limit normal (ULN), albumin ≥2.0g/dL, total bilirubin ≤3.5mg/dL Sodium: ≥130mEq/L
- Karnofsky Performance Status of ≥ 60%
- CLIP Score ≤ 3
- If female and of childbearing potential, must use an effective method of contraception
- Willing and able to provide written informed consent
Exclusion
- Has received localized therapy (e.g., radiotherapy, RFA, injection therapy, or chemoembolization)within 6 weeks prior to treatment, Day1. Prior local lesion-specific radiotherapy is acceptable only if the treated lesion(s) is/are not the only source of measurable disease or there is documented progression of the treated lesion(s) following completion of the therapy.
- Has received any other systemic therapy for HCC within 3 weeks prior to treatment, Day 1. Prior therapy is acceptable only if there is documented progression following completion of the therapy.
- Has received another investigational therapy within 30 days prior to study entry
- Has any unstable serious or life-threatening medical condition, other than HCC (e.g., unstable angina, other cancer diagnosis with the exception of basal cell carcinoma, or patients with prior malignancy except for adequately treated basal cell carcinoma(s), in situ cervical cancer, or other cancer for which the patient has been disease-free for five or more years)
- Newly noted clinically significant electrocardiogram (ECG) abnormality
- Clinically significant abnormal laboratory result that is not consistent with patient's clinical course
- Active gastrointestinal bleeding resulting in clinically significant hemodynamic changes or a reduction in hemoglobin.
- Active inflammatory bowel disease (IBD) and/or active gastric or duodenal ulcer disease
- Has a history of central nervous system (CNS) metastases, seizure disorder or neurological exam finding suggestive of CNS metastases
- Has Stage B or C liver cirrhosis according to Child-Pugh-Turcotte Classification
- Has ascites refractory to diuretic therapy
- Has any contraindication for MRI procedure
- If female of childbearing potential, has a positive serum HCG
- If female, is lactating
Key Trial Info
Start Date :
March 1 2004
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 1 2007
Estimated Enrollment :
38 Patients enrolled
Trial Details
Trial ID
NCT00081900
Start Date
March 1 2004
End Date
November 1 2007
Last Update
April 13 2015
Active Locations (8)
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1
University of Illinois- Chicago
Chicago, Illinois, United States, 60612-7323
2
Massachusetts General Hospital
Boston, Massachusetts, United States, 02114
3
Beth Israel Deaconess Medical Center
Boston, Massachusetts, United States, 02215
4
Dana Farber Partners Cancer Care
Boston, Massachusetts, United States