Status:
COMPLETED
Isoproterenol Challenge to Detect Arrhythmogenic Right Ventricular Cardiomyopathy
Lead Sponsor:
National Institutes of Health Clinical Center (CC)
Conditions:
Arrhythmic Right Ventricular Cardiomyopathy
Eligibility:
All Genders
Brief Summary
This study will examine the usefulness of a new test called an isoproterenol challenge in patients with arrhythmogenic right ventricular cardiomyopathy (ARVC) and family members who may have the disea...
Detailed Description
Arrhythmogenic right ventricular cardiomyopathy (ARVC) formerly referred to as arrhythmogenic right ventricular dysplasia (ARVD) is a familial hetergenous clinical and molecular disease characterized ...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- Patients with ARVC:
- Either gender, aged greater than 5 years.
- The presence of two major criteria; one major and two minor criteria; or four minor criteria from separate diagnostic categories.
- Normal Volunteers:
- Age and gender matched with ARVC patients, age greater than 18 years.
- No known cardiac disease.
- Normal EKG, normal echocardiogram, normal Bruce protocol treadmill exercise test.
- Family Members of Patients with ARVC:
- Either gender, aged greater than 5 years.
- A proband with ARVC
- EXCLUSION CRITERIA:
- Patients with ARVC:
- Pregnancy or lactation excludes tests with potential risk, e.g. radiation, isoprenaline, MRI, but does not exclude 12-lead ECG and echocardiogram.
- Coronary artery disease.
- Known infiltrate or congenital heart disease that could mimic the appearances of ARVC.
- Asthma prevents participation in Isoproterenol infusion.
- Any other condition that would prevent participation in the study.
- Normal Volunteers:
- Pregnancy or lactation.
- Asthma.
- Coronary artery disease, hypertension, diabetes, hypertrophic cardiomyopathy, or other known cardiomyopathy.
- Known infiltrative or congenital heart disease that could mimic the appearances of ARVC.
- Any Acute or chronic illness.
- Chronic drug therapy.
- Family Members of Patients with ARVC:
- Pregnancy or lactation excludes tests with potential risk, e.g. radiation, isoprenaline, MRI, but does not exclude 12-lead ECG and echocardiogram.
- Coronary artery disease.
- Known infiltrative or congenital heart disease that could mimic the appearances of ARVC.
- Asthma prevents participation in Isoproterenol infusion.
- Any other condition that would prevent participation in the study.
Exclusion
Key Trial Info
Start Date :
May 1 2004
Trial Type :
OBSERVATIONAL
End Date :
December 1 2005
Estimated Enrollment :
160 Patients enrolled
Trial Details
Trial ID
NCT00083395
Start Date
May 1 2004
End Date
December 1 2005
Last Update
March 4 2008
Active Locations (1)
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1
National Institutes of Health Clinical Center (CC)
Bethesda, Maryland, United States, 20892