Status:
COMPLETED
Use of [18F]FECNT in Positron Emission Tomography
Lead Sponsor:
National Institute of Mental Health (NIMH)
Conditions:
Healthy
Eligibility:
All Genders
Phase:
PHASE1
Brief Summary
This study will examine the use of a new radioactive tracer called \[18F\]FECNT in positron emission tomography (PET) scanning for measuring dopamine transporter (DAT) in the brain. DAT is found in br...
Detailed Description
The dopamine system plays important roles in various neurological and psychiatric disorders such as Parkinson's disease, schizophrenia, mood disorders, and attention-deficit hyperactivity disorder. Se...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- Healthy subjects ages 18-65
- EXCLUSION CRITERIA-WHOLE BODY IMAGING:
- Current diagnosis of psychiatric disease, substance dependence or severe systemic disease.
- History of substance abuse within 6 months.
- Abnormal laboratory tests.
- Prior participation in other research protocols within the past year such that a radiation exposure together with the present study would exceed the annual limits.
- Pregnancy and breast feeding.
- HIV positive.
- EXCLUSION CRITERIA-DYNAMIC BRAIN IMAGING:
- Current diagnosis of psychiatric disease, substance dependence or severe systemic disease.
- History of substance abuse within 6 months.
- Abnormal laboratory tests.
- Novocain allergy.
- Prior participation in other research protocols within the past year such that a radiation exposure together with the present study would exceed the annual limits.
- Any condition that increases increase risk for MRI (e.g., pacemaker, metallic foreign body in the eye).
- Pregnancy and breast feeding.
- HIV positive.
Exclusion
Key Trial Info
Start Date :
May 1 2004
Trial Type :
INTERVENTIONAL
End Date :
September 1 2005
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT00083629
Start Date
May 1 2004
End Date
September 1 2005
Last Update
March 4 2008
Active Locations (1)
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1
National Institute of Mental Health (NIMH)
Bethesda, Maryland, United States, 20892