Status:
ACTIVE_NOT_RECRUITING
Analysis of Specimens From Individuals With Pulmonary Fibrosis
Lead Sponsor:
National Human Genome Research Institute (NHGRI)
Conditions:
Pulmonary Fibrosis
Healthy Volunteers
Eligibility:
All Genders
18-115 years
Brief Summary
The etiology of pulmonary fibrosis is unknown. Analyses of blood, genomic DNA, and specimens procured by bronchoscopy, lung biopsy, lung transplantation, clinically-indicated extra-pulmonary biopsies,...
Detailed Description
The etiology of pulmonary fibrosis is unknown. Analyses of blood, genomic DNA, and specimens procured by bronchoscopy, lung biopsy, lung transplantation, clinically-indicated extra-pulmonary biopsies,...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- Individuals who are 18 years of age or older with any of the following:
- Idiopathic pulmonary fibrosis \[defined by the American Thoracic Society/European Respiratory Society guidelines\],
- Familial pulmonary fibrosis \[defined as idiopathic pulmonary fibrosis in two or more first-degree relatives\],
- Relatives of patients with hereditary pulmonary fibrosis,
- Hermansky-Pudlak syndrome (diagnosed by paucity or deficiency of platelet dense bodies on whole mount electron microscopy or by genetic testing),
- Pulmonary fibrosis associated with collagen vascular diseases or autoinflammatory disorders,
- Pulmonary fibrosis post-COVID-19 \[i.e., pulmonary fibrosis in an individual recovering from SARS-CoV-2 infection\], or
- Healthy research volunteers by history and indicated tests (individuals without history of chronic pulmonary disorder, collagen vascular disease, or bleeding disorder).
- EXCLUSION CRITERIA:
- Individuals with any of the following:
- Significant inhalational exposure to fibrogenic fibers or dusts or exposure to drugs associated with pulmonary fibrosis,
- Uncontrolled ischemic heart disease,
- Uncorrectable bleeding diathesis,
- Pregnancy or lactation (excluded due to exposure of unnecessary risks), or
- Inability to give informed consent (excluded due to exposure of unnecessary risks).
Exclusion
Key Trial Info
Start Date :
June 9 2004
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
Estimated Enrollment :
315 Patients enrolled
Trial Details
Trial ID
NCT00084305
Start Date
June 9 2004
Last Update
January 5 2026
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892