Status:
COMPLETED
Tipifarnib and Erlotinib Hydrochloride in Treating Patients With Advanced Solid Tumors
Lead Sponsor:
National Cancer Institute (NCI)
Conditions:
Solid Neoplasm
Eligibility:
All Genders
18+ years
Phase:
PHASE1
Brief Summary
This phase I trial studies the side effects and best dose of tipifarnib and erlotinib hydrochloride in treating patients with solid tumors that have spread to other places in the body. Tipifarnib and ...
Detailed Description
PRIMARY OBJECTIVES: I. To determine the maximal tolerated dose of R115777 (tipifarnib) in combination with OSI-774 (erlotinib hydrochloride). II. To describe the toxicity profile of this combination...
Eligibility Criteria
Inclusion
- Histologic proof of cancer that is unresectable and for which no standard life-prolonging therapy is available
- Absolute neutrophil count (ANC) \>= 1500/uL
- Platelet count (PLT) \>= 100,000/uL
- Total bilirubin =\< 2 mg/dL
- Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =\< 2.5 x upper limit of normal (ULN)
- Creatinine =\< 1.5 x ULN
- Hemoglobin (Hgb) \>= 9.0 g/dL
- Ability to provide informed consent
- Willingness to return to Mayo Clinic Rochester for follow up
- Life expectancy \>= 12 weeks
- At maximum tolerated dose (MTD) only: tumor that is amenable for serial biopsy
- Medically capable and willing to provide the biologic specimens as required by the protocol Note: The goals of this study include assessment of the biologic effects on surrogate markers of the agent(s) being tested and are, therefore, contingent upon availability of the biologic specimens; patients with pre-existing clinical contraindications (e.g. anticoagulant therapy) for biopsy will be excluded from participation in the study; however, those patients who develop a major complication associated with the first biopsy (e.g. bleeding) or who develop clinical contraindications (e.g., anticoagulant therapy) after entry on study may remain on the study without the requirement for further tissue biopsies; this stipulation only applies to the 12 patients enrolled in Cohort II at MTD; the stipulation for provision of biologic specimens, as noted above, excludes the optional pharmacogenomic specimen
Exclusion
- Known standard therapy for the patient's disease that is potentially curative or definitely capable of extending life expectancy
- Eastern Cooperative Oncology Group (ECOG) performance status (PS) 2, 3, or 4
- Uncontrolled infection
- Any of the following prior therapies:
- Chemotherapy =\< 4 weeks prior to study entry
- Mitomycin C/nitrosoureas =\< 6 weeks prior to study entry
- Immunotherapy =\< 4 weeks prior to study entry
- Biologic therapy =\< 4 weeks prior to study entry
- Hormonal cancer therapy =\< 4 weeks prior to study entry
- Radiation therapy =\< 4 weeks prior to study entry
- Radiation to \> 25% of bone marrow
- Failure to fully recover from acute, reversible effects of prior chemotherapy regardless of interval since last treatment
- New York Heart Association classification III or IV
- Patients on enzyme-inducing anticonvulsants (Phenobarbital, Dilantin, or Tegretol)
- Any of the following:
- Pregnant women
- Nursing women
- Men or women of childbearing potential who are unwilling to employ adequate contraception (condoms plus spermicidal agents, diaphragm, birth control pills, injections, intrauterine device \[IUD\], or abstinence, etc.)
- Other concurrent chemotherapy, immunotherapy, radiotherapy, or any ancillary therapy considered investigational (utilized for a non-Food and Drug Administration \[FDA\]-approved indication and in the context of a research investigation)
- Uncontrolled intercurrent illness including, but not limited to:
- Ongoing or active infection
- Symptomatic congestive heart failure
- Unstable angina pectoris
- Cardiac arrhythmia
- Psychiatric illness/social situations that would limit compliance with study requirements
- Prior treatment with EGFR targeting therapies (e.g., ZD-1869, EKB-569, OSI-774, CI-1033, GW572016, C225, EMD72000) or Farnesyl transferase inhibitors (R115777, SCH66336, BMS2146632)
- Major surgery, or significant traumatic injury occurring =\< 21 days prior to study entry
- Abnormalities of the cornea based on history (e.g., dry eye syndrome, Sjögren's syndrome), congenital abnormality (e.g., Fuch's dystrophy), abnormal slit-lamp examination using a vital dye (e.g., fluorescein, Bengal-Rose), and/or an abnormal corneal sensitivity test (Schirmer test or similar tear production test)
- Gastrointestinal tract disease resulting in an inability to take oral or nasogastric medication or a requirement for intravenous (IV) alimentation, prior surgical procedures affecting absorption, or active peptic ulcer disease
- Human immunodeficiency virus (HIV)-positive patients receiving combination anti-retroviral therapy
- Known brain metastases unless treated with surgery and/or radiation and stable for \>= 8 weeks; patient should not be on enzyme-inducing anticonvulsants (Phenobarbital, Phenytoin (Dilantin) or Carbamazepine (Tegretol))
Key Trial Info
Start Date :
May 20 2004
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 16 2018
Estimated Enrollment :
29 Patients enrolled
Trial Details
Trial ID
NCT00085553
Start Date
May 20 2004
End Date
May 16 2018
Last Update
May 18 2018
Active Locations (1)
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1
Mayo Clinic
Rochester, Minnesota, United States, 55905