Status:
COMPLETED
Effects of Anorexia Nervosa on Bone Mass in Adolescents
Lead Sponsor:
Massachusetts General Hospital
Collaborating Sponsors:
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
The Hospital for Sick Children
Conditions:
Anorexia Nervosa
Eligibility:
FEMALE
12-18 years
Phase:
PHASE2
PHASE3
Brief Summary
This study is to determine the effects of anorexia nervosa on bone mass and hormone levels in adolescents. Whether administration of estrogen, a normal hormone present during puberty, can help maintai...
Detailed Description
Adolescence is a critical time for bone mineral accretion as between 60-90% of peak bone mass is established during this period, and peak bone mass is a major determinant of bone density and osteoporo...
Eligibility Criteria
Inclusion
- Females Only with Anorexia Nervosa and Amenorrhea 12-18 years
- Normal-weight girls 12-18 years with no past or present history of an eating disorder
Exclusion
- Diseases affecting bone metabolism (including untreated thyroid disease, premature ovarian failure, diabetes, cancer, pituitary, renal disease or bone fracture within the past six months)
- Use of prescription medications affecting bone metabolism within three months
- Suicidality
- Psychosis
- Substance abuse
- Hematocrit \<30 %
- Potassium \<3.0 mmol/L
- Glucose \<50 mg/dl.
Key Trial Info
Start Date :
July 1 2003
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2011
Estimated Enrollment :
110 Patients enrolled
Trial Details
Trial ID
NCT00088153
Start Date
July 1 2003
End Date
June 1 2011
Last Update
November 2 2021
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Massachusetts General Hospital
Boston, Massachusetts, United States, 02114