Decentrialz logo
  • HIPAA Compliant
  • ISO 27001 Certified
Find Trials
About UsContact
Become a Volunteer+1 877 705 1914

Status:

COMPLETED

Alvespimycin Hydrochloride in Treating Patients With Metastatic or Unresectable Solid Tumors

Lead Sponsor:

National Cancer Institute (NCI)

Conditions:

Male Breast Cancer

Recurrent Adenoid Cystic Carcinoma of the Oral Cavity

Eligibility:

All Genders

18+ years

Phase:

PHASE1

Brief Summary

This phase I trial is studying the side effects and best dose of alvespimycin hydrochloride in treating patients with metastatic or unresectable solid tumors. Drugs used in chemotherapy, such as alves...

Detailed Description

PRIMARY OBJECTIVES: I. Determine the toxic effects and maximum tolerated dose of 17-dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG) in patients with metastatic or unresectable solid tumors...

Eligibility Criteria

Inclusion

  • Inclusion Criteria:
  • Histologically confirmed solid tumor, including, but not limited to, the following:
  • Prostate
  • Breast
  • Ovary
  • Colon
  • Kidney
  • Head and neck
  • Stomach
  • Melanoma
  • Metastatic or unresectable disease
  • No standard curative or palliative therapy exists or is no longer effective
  • Progressive disease as indicated by the following:
  • Non-prostate cancer
  • New lesions or increase in pre-existing lesions on bone scintigraphy, CT scan, MRI, or by physical examination
  • No increase in biochemical markers (e.g., carcinoembryonic antigen or CA-15-3) or symptoms as sole evidence of disease progression
  • Prostate cancer
  • Must have castrate metastatic disease (i.e., disease progression after castration or treatment with a gonadotropin-releasing hormone \[GnRH\] analog)
  • Patients who have not undergone surgical orchiectomy must continue with medical therapy (i.e., GnRH analogs) to maintain castrate levels of serum testosterone \< 50 ng/dL
  • Patients who received an antiandrogen as part of first-line hormonal therapy must show disease progression after discontinuing treatment
  • Progressive metastatic disease on imaging studies (e.g., bone scan, CT scan, or MRI) OR metastatic disease and a rising prostate-specific antigen (PSA) allowed
  • Biochemical progression is defined as a minimum of 3 rising PSA values from baseline obtained at least 1 week apart OR 2 rising PSA values obtained more than 1 month apart, with \>= 25% increase in value
  • No active brain metastases
  • Hormone receptor status:
  • Not specified
  • Male or female
  • Performance status - Karnofsky 70-100%
  • Performance status - ECOG 0-1
  • More than 6 months
  • WBC \>= 3, 000/mm\^3
  • Absolute neutrophil count \>= 1, 500/mm\^3
  • Platelet count \>= 100,000/mm\^3
  • Bilirubin =\< 1.5 times upper limit of normal (ULN)
  • AST and ALT \< 1.5 times ULN
  • PT normal
  • Creatinine =\< 1.4 mg/dL
  • Creatinine clearance \> 55 mL/min
  • QTc \< 450 msec for male patients (470 msec for female patients)
  • LVEF \> 40% by MUGA
  • No history of serious ventricular arrhythmia (i.e., ventricular tachycardia or ventricular fibrillation \>= 3 beats in a row)
  • No myocardial infarction within the past year
  • No active ischemic heart disease within the past year
  • No New York Heart Association class III or IV congestive heart failure
  • No congenital long QT syndrome
  • No left bundle branch block
  • No poorly controlled angina
  • No history of uncontrolled dysrhythmias or requiring antiarrhythmic drugs
  • Calcium blockers and beta blockers allowed
  • No other significant cardiac disease
  • Oxygen saturation \> 88%
  • Dyspnea \< grade 2 at rest on room air
  • No clinically significant pulmonary comorbidity (e.g., severe chronic obstructive pulmonary disease)
  • No requirement for supplemental oxygen
  • Not pregnant or nursing
  • Negative pregnancy test
  • Fertile patients must use effective contraception
  • No active or ongoing infection
  • No symptomatic peripheral neuropathy \>= grade 2
  • No psychiatric illness or social situation that would preclude study compliance
  • No other uncontrolled illness
  • More than 4 weeks since prior chemotherapy (6 weeks for mitomycin and nitrosoureas)
  • At least 1 week since prior ketoconazole
  • More than 4 weeks since prior radiotherapy
  • Recovered from all prior therapy
  • More than 4 weeks since prior investigational anticancer therapeutic drugs
  • No concurrent combination antiretroviral therapy for HIV-positive patients
  • No concurrent administration of any of the following herbal remedies:
  • Hydrastis canadensis (goldenseal)
  • Hypericum perforatum (St. John's wort)
  • Uncaria tomentosa (cat's claw)
  • Echinacea angustifolia roots
  • Trifolium pratense (wild cherry)
  • Matricaria chamomilla (chamomile)
  • Glycyrrhiza glabra (licorice)
  • Dillapiol
  • Hypericin
  • Naringenin
  • No other concurrent investigational agents
  • No other concurrent anticancer agents or therapies

Exclusion

    Key Trial Info

    Start Date :

    July 1 2004

    Trial Type :

    INTERVENTIONAL

    Allocation :

    ACTUAL

    End Date :

    Estimated Enrollment :

    30 Patients enrolled

    Trial Details

    Trial ID

    NCT00089362

    Start Date

    July 1 2004

    Last Update

    April 10 2013

    Active Locations (1)

    Enter a location and click search to find clinical trials sorted by distance.

    Page 1 of 1 (1 locations)

    1

    Memorial Sloan Kettering Cancer Center

    New York, New York, United States, 10065