Status:
COMPLETED
Immune Indicators of Uveitis
Lead Sponsor:
National Eye Institute (NEI)
Conditions:
GITR
GITR Ligand
Eligibility:
All Genders
18+ years
Brief Summary
This study will try to identify markers of immune activity in uveitis patients that correlate with the state of disease activity. Uveitis is a group of inflammatory eye diseases that can cause vision ...
Detailed Description
Indicators of disease activity in supposed autoimmune conditions are actively being sought. We have already described the increased expression of GITR-glucocorticoid induced TNF-related family recepto...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- Patients with bilateral sight threatening uveitis requiring systemic immunotherapy who are 18 years and older are eligible. Disease can be active or quiescent, but subjects must be on a minimum prescribed therapy upon enrollment of a dose averaging at least 20 mg/day (or greater than or equal to 0.25 mg/kg/day) of systemic prednisone or a more intensive immunosuppression regimen. More intensive regimens may include from one to three anti-inflammatory treatments for uveitis that include any one of the following (or related) compounds: corticosteroids (including systemic or periorbital administration), topical corticosteroids (when used in combination with other agents), cyclophosphamide, cyclosporine, azathioprine, chlorambucil, tacrolimus, leflunomide, mycophenolate mofetil, or methotrexate.
- Patients who have non-infectious intermediate, posterior, or panuveitis of at least 3 months duration. Included conditions may include but are not limited to intermediate uveitis of the pars planitis subtype, sarcoidosis, the Vogt-Koyanagi-Harada (VKH) syndrome, birdshot retinochoroidopathy, retinal vasculitis and sympathetic ophthalmia.
- Patients who are 18 years of age or older.
- EXCLUSION CRITERIA:
- Subjects will not be able to enroll if they:
- Are unwilling or unable to give blood at the designated times in the protocol.
- Have another disease or condition affecting vision that will interfere with obtaining study data
- Are pregnant
Exclusion
Key Trial Info
Start Date :
August 9 2004
Trial Type :
OBSERVATIONAL
End Date :
October 28 2008
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT00089739
Start Date
August 9 2004
End Date
October 28 2008
Last Update
July 2 2017
Active Locations (1)
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1
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States, 20892