Status:
COMPLETED
Biochemical and Genetic Markers of Hypertension in Women
Lead Sponsor:
Brigham and Women's Hospital
Collaborating Sponsors:
National Heart, Lung, and Blood Institute (NHLBI)
Conditions:
Cardiovascular Diseases
Hypertension
Eligibility:
FEMALE
50-70 years
Brief Summary
To investigate biochemical and genetic markers of inflammation and endothelial dysfunction as determinants of hypertension.
Detailed Description
BACKGROUND: Hypertension affects up to 50 million Americans, and is a major risk factor for cardiovascular disease and other health outcomes. Among Black women, hypertension is more prevalent, less w...
Eligibility Criteria
Inclusion
- We included White and Black WHI-OS participants aged \<70 years, and excluded women with any baseline history of hypertension (via self-report, measured BP, or medication use), non-melanoma cancer, myocardial infarction, revascularization procedures, congestive heart failure, angina pectoris, or stroke. Further, women developing myocardial infarction or stroke, or dying from coronary heart disease or stroke during follow-up were excluded. Only for potential hypertension cases, women with revascularization procedures, congestive heart failure, angina pectoris, or non-melanoma cancer prior to or \<30 days after the diagnosis of hypertension were also excluded. Finally, we excluded women with inadequate bloods or who refused to participate in a genetic study.
Exclusion
Key Trial Info
Start Date :
August 1 2004
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
July 1 2008
Estimated Enrollment :
1600 Patients enrolled
Trial Details
Trial ID
NCT00090467
Start Date
August 1 2004
End Date
July 1 2008
Last Update
July 30 2013
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