Status:
UNKNOWN
Chemotherapy for Patients With Advanced Solid Tumors or Non-Hodgkin's Lymphoma
Lead Sponsor:
Novacea
Conditions:
Solid Malignancies
Non-Hodgkin's Lymphoma
Eligibility:
All Genders
18+ years
Phase:
PHASE1
Brief Summary
The purposes of this study are to determine: * the largest dose of AQ4N that can be safely given once a week for three weeks out of a 4 week cycle * the side effects of AQ4N when given on the above s...
Detailed Description
This study is for people who have advanced cancer for which standard chemotherapy did not work or for which there are no reliably, effective treatments. AQ4N is an experimental chemotherapy that is t...
Eligibility Criteria
Inclusion
- Advanced solid malignancy or non-Hodgkin's lymphoma that is refractory to treatment or has recurred
- Age \> 18 years
- Adequate hematologic (blood), kidney and liver function
- Negative pregnancy test (females of childbearing potential only)
- Willingness to use effective contraception by both males and females throughout the treatment period and for at least 2 months following treatment.
Exclusion
- Any chemotherapy or radiation within the past 4 weeks
- Symptomatic or uncontrolled brain metastases (patients with history of brain metastases who have had repeat brain scans within the past 30 days that demonstrate no evidence of tumor progression or brain swelling and who do not require corticosteriod treatment may be eligible)
- Significant cardiovascular illness including, but not limited to, the following: active infection, uncontrolled hypertension, symptomatic congestive heart failure, unstable angina pectoris, heart attack within the past six months, or uncontrolled, irregular heart beat
- Inadequate cardiac function
- Prior investigational therapy within the past 28 days
- Pregnant or breast feeding women
Key Trial Info
Start Date :
August 1 2004
Trial Type :
INTERVENTIONAL
End Date :
Estimated Enrollment :
45 Patients enrolled
Trial Details
Trial ID
NCT00090727
Start Date
August 1 2004
Last Update
November 2 2006
Active Locations (2)
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1
Weiler Hospital of Albert Einstein College of Medicine
The Bronx, New York, United States, 10461
2
Cancer Therapy & Research Center / Institute for Drug Development
San Antonio, Texas, United States, 78229