Status:
COMPLETED
Effectiveness of Depression Treatment Following Coronary Artery Bypass Surgery
Lead Sponsor:
University of Pittsburgh
Collaborating Sponsors:
National Heart, Lung, and Blood Institute (NHLBI)
Conditions:
Cardiovascular Diseases
Coronary Disease
Eligibility:
All Genders
18-100 years
Phase:
NA
Brief Summary
The purpose of this study is to treat depression in patients who have undergone coronary artery bypass graft (CABG).
Detailed Description
BACKGROUND: Cardiovascular disease morbidity and mortality is an important health issue. Depression has emerged as a risk factor for increased morbidity and mortality in patients with coronary heart ...
Eligibility Criteria
Inclusion
- Recently underwent CABG (combined or redo procedure) at one of 8 Pittsburgh area study hospitals
- A PHQ score greater than 10 OR if nondepressed control, a PHQ score less than 5 at both 2 days post CABG to the date of discharge following CABG and when reassessed 2 weeks after hospital discharge
- Folstein Mini-Mental State Examination (MMSE) score greater than or equal to 24
- Able to be evaluated and treated for depression as an outpatient post CABG
- Has a household telephone
Exclusion
- Presently in treatment with a mental health specialist
- Actively suicidal
- History of psychotic illness
- History of bipolar illness according to subject self-report and past medical history
- Current alcohol dependence or other substance abuse as evidenced by chart review and the CAGE questionnaire
- Organic mood syndromes, including those secondary to medical illness or drugs
- Presence of non-cardiovascular conditions that are likely to be fatal within 1 year
- Unstable medical condition as indicated by history, physical, and/or laboratory findings
- Previous enrollment in the study cohort
- Non-English speaking, illiterate, or possessing any other communication barrier
- If nondepressed control, current or previous diagnosis or treatment of depression
Key Trial Info
Start Date :
August 1 2003
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2009
Estimated Enrollment :
453 Patients enrolled
Trial Details
Trial ID
NCT00091962
Start Date
August 1 2003
End Date
December 1 2009
Last Update
April 14 2016
Active Locations (1)
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1
University of Pittsburgh School of Medicine
Pittsburgh, Pennsylvania, United States, 15213