Status:
UNKNOWN
Predictors of Cognitive Decline in Normal Aging
Lead Sponsor:
National Institute on Aging (NIA)
Conditions:
Alzheimer Disease
Dementia
Eligibility:
All Genders
60-80 years
Brief Summary
The goal of this project is to develop an early diagnostic test for Alzheimer's disease (AD) by monitoring loss of neurons and brain size reductions over a period of five years.
Detailed Description
Studies of normal aging and mild cognitive impairment (MCI) show that loss of neurons and reduction in size of the hippocampal part of the brain predict a person's conversion from MCI to Alzheimer's d...
Eligibility Criteria
Inclusion
- Males and females, from all racial and ethnic categories between the ages of 60-80 years of age, with English as their first language.
- Residents of the New York City metropolitan area.
- Minimum of 12 years of education.
- Participants will be grouped according to the following classifications: normal aging, mild cognitive impairment (MCI), Alzheimer's disease (AD), or frontotemporal dementia (FTD).
- Participants will agree to ApoE genotyping and DNA banking.
Exclusion
- Past history or MRI evidence of brain damage including significant trauma, stroke, hydrocephalus, lacunar infarcts, seizures, mental retardation or serious neurological disorder.
- Significant history of alcoholism or drug abuse.
- History of psychiatric illness (e.g., schizophrenia, mania or depression).
- Any focal signs or significant neuropathology.
- A score of 4 or greater on the Modified Hachinski Ischemia Scale suggesting cerebrovascular disease.
- A total score of 16 or more on the Hamilton Depression Scale to exclude possible cases of primary depression.
- Evidence of clinically relevant and uncontrolled hypertensive, cardiac, pulmonary, vascular, metabolic or hematologic conditions.
- Physical impairment of such severity as to adversely affect the validity of psychological testing.
- Hostility or refusal to cooperate.
- Any prosthetic devices (e.g., pacemaker or surgical clips) that could be affected by the magnetic field employed during MRI imaging.
- History of familial early onset dementia.
Key Trial Info
Start Date :
September 1 2003
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
August 1 2008
Estimated Enrollment :
170 Patients enrolled
Trial Details
Trial ID
NCT00094939
Start Date
September 1 2003
End Date
August 1 2008
Last Update
December 14 2009
Active Locations (1)
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1
Center for Brain Health, Silberstein Institute, New York University School of Medicine
New York, New York, United States, 10016