Status:
COMPLETED
Detecting Abnormal Blood Clotting in Patients With Metastatic Cancer Undergoing Surgery
Lead Sponsor:
National Cancer Institute (NCI)
Conditions:
Thromboembolism
Unspecified Adult Solid Tumor, Protocol Specific
Eligibility:
All Genders
18+ years
Brief Summary
RATIONALE: A test that detects abnormal blood clotting in patients with cancer may help doctors plan cancer surgery. PURPOSE: This laboratory study is looking at a new blood test to detect abnormal c...
Detailed Description
OBJECTIVES: Primary * Determine whether whole blood thrombin generation assay (WBTGA) detects hypercoagulability in patients with metastatic carcinoma compared with a healthy control group. * Determ...
Eligibility Criteria
Inclusion
- DISEASE CHARACTERISTICS:
- Patients meeting the following criteria:
- Diagnosis of metastatic carcinoma
- Must be enrolled in 1 of the following surgical protocols:
- NCI-99-C-0123
- NCI-00-C-0069
- NCI-03-C-0085
- NCI-03-C-0212
- Healthy control participant\* meeting the following criteria:
- No anemia or thrombocytopenia
- No history of venous thromboembolism (deep vein thrombosis, pulmonary emboli)
- No history of coronary artery disease or stroke
- No chronic inflammatory disease
- No diabetes mellitus
- Have not smoked tobacco within the past 6 months NOTE: \* Selected on the basis of gender and age to match the patients as they are accrued
- PATIENT CHARACTERISTICS:
- No symptomatic infections or other acute illness within the past 14 days
- PRIOR CONCURRENT THERAPY:
- At least 3 days since prior drugs known to inhibit platelet function
- At least 7 days since prior acetylsalicylic acid
- No concurrent estrogen contraceptives or hormone replacement therapy
- No concurrent anticoagulants
Exclusion
Key Trial Info
Start Date :
November 1 2004
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT00096590
Start Date
November 1 2004
Last Update
May 12 2009
Active Locations (1)
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1
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States, 20892