Status:
COMPLETED
CALERIE (Tufts) - Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy
Lead Sponsor:
National Institute on Aging (NIA)
Conditions:
Aging
Eligibility:
All Genders
25-50 years
Phase:
PHASE1
Brief Summary
This study is one of three CALERIE trials that test the hypothesis that a reduced calorie, nutritionally sound diet increases the length of life and prevents some age-related chronic diseases such as ...
Detailed Description
Researchers at the Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University are enrolling overweight men and women aged 20-42 in a 1-year study to develop an effective calorie rest...
Eligibility Criteria
Inclusion
- Inclusion Criteria
- Healthy men and women
- Body mass index (BMI) = 25-30
- Slightly overweight, \< 275 lbs
- Women 25-45, pre-menopause
- Men 25-50
- Not traveling often or planning to move
- Exclusions:
- Cardiovascular disease or blood pressure greater than 160/90
- Diabetes
- Major psychiatric disorders
- Eating disorders
- Post obese; previous BMI \> 32
- Weight change of more than ten pounds in the past 90 days
- Over 275 pounds
- Smoking
- Regular exercise, more than twice per week
- Current prescription drug use, except oral contraceptives
- Alcoholism or substance abuse
- Pregnant or lactating (breast feeding), planning to become pregnant, or not regularly using contraception
- Abnormal electrocardiogram (EKG)
- Local resident for less than one year
- Occupations requiring full alertness and motor skills, with no allowance for a chance of postural dizziness (airline pilots, etc.)
- Injuries by any metallic object that is still present in the body
- Braces, non-removable dentures, or non-removable bridgework
Exclusion
Key Trial Info
Start Date :
March 1 2002
Trial Type :
INTERVENTIONAL
End Date :
December 1 2004
Estimated Enrollment :
44 Patients enrolled
Trial Details
Trial ID
NCT00099099
Start Date
March 1 2002
End Date
December 1 2004
Last Update
December 11 2009
Active Locations (1)
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1
Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University
Boston, Massachusetts, United States, 02111-1524