Status:
COMPLETED
Effect of Solar-Simulated Ultraviolet Radiation on Gene Expression in Unprotected and Sunscreen-Protected Skin of Healthy Adults With Fitzpatrick Skin Type II
Lead Sponsor:
National Cancer Institute (NCI)
Conditions:
Non-melanomatous Skin Cancer
Precancerous Condition
Eligibility:
All Genders
18-45 years
Brief Summary
RATIONALE: Testing of skin that has been exposed to artificial sunlight may help in understanding the genetic processes involved in the development of skin cancer. PURPOSE: This trial is studying the...
Detailed Description
OBJECTIVES: * Determine the global gene expression profiles in epidermal tissue of healthy fair-skinned adults with Fitzpatrick skin type II after exposure to known doses of solar-simulated ultraviol...
Eligibility Criteria
Inclusion
- DISEASE CHARACTERISTICS:
- Healthy, fair-skinned adults
- Fitzpatrick skin type II by history and physical exam
- Skin easily burns, and tans only slightly, after sun exposure
- Test site for solar-simulated ultraviolet radiation exposure (buttocks) devoid of sunburn, suntan, scars, active dermal lesions, and uneven skin tones
- Nevi allowed at physician discretion
- Excess hair must be clipped or shaved
- No prior nonmelanoma skin cancer, melanoma, or dysplastic nevi
- PATIENT CHARACTERISTICS:
- Age
- 18 to 45
- Performance status
- Not specified
- Life expectancy
- Not specified
- Hematopoietic
- Not specified
- Hepatic
- Not specified
- Renal
- Not specified
- Other
- No prior malignancy
- No prior phototoxic, photoallergic, or other abnormal responses to sunlight
- No prior allergic reaction to sunscreen or lidocaine
- No underlying disease that is known to cause immunosuppression (e.g., HIV, cancer, or post-organ transplantation)
- No situation that would preclude study compliance
- Not pregnant or nursing
- PRIOR CONCURRENT THERAPY:
- Biologic therapy
- Not specified
- Chemotherapy
- Not specified
- Endocrine therapy
- Not specified
- Radiotherapy
- Not specified
- Surgery
- Not specified
- Other
- More than 6 months since prior topical or systemic medication producing abnormal sunlight responses
- No concurrent medications with \> 1% incidence of sun-related toxic effects
- No concurrent medications associated with abnormal light response
- No concurrent immunosuppressants
- No other concurrent ultraviolet radiation (e.g., sunlight or tanning bed) to the epidermal test site
Exclusion
Key Trial Info
Start Date :
February 1 2004
Trial Type :
OBSERVATIONAL
End Date :
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT00099112
Start Date
February 1 2004
Last Update
April 30 2015
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Warren Grant Magnuson Clinical Center - NCI Clinical Studies Support
Bethesda, Maryland, United States, 20892-1182