Status:
COMPLETED
Brain Reorganization Following Constraint-Induced Therapy in Children With Cerebral Palsy
Lead Sponsor:
National Institute of Neurological Disorders and Stroke (NINDS)
Conditions:
Cerebral Palsy
Eligibility:
All Genders
7-17 years
Brief Summary
This study will examine how therapy changes the way the brain controls movements in children with cerebral palsy. Normally, one side of the brain controls movements in the opposite side of the body. I...
Detailed Description
Objective: To determine the underlying brain reorganization that occurs in children with hemiplegic cerebral palsy before and after pediatric Constraint-Induced therapy. Background: A promising new t...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- Children 9 to 17 years of age.
- Cerebral palsy patients:
- Children previously diagnosed with spastic hemiplegia subtype of cerebral palsy
- Children with non-progressive cerebral lesions acquired pre-, peri- or post-natally, before 1 year of age.
- Typically Developing subjects:
- Scores below 60 on Connor's attention deficit/hyperactivity disorder (ADHD) checklist.
- Normal neurological history and examination
- EXCLUSION CRITERIA:
- Any child who is pregnant
- Patients with Development Quotient (DQ) or Intelligence Quotient (IQ) below 50 on standardized tests
- Cerebral palsy patients:
- Children with subtypes of cerebral palsy that are not hemiplegia.
- Children with uncontrolled seizures within the last 6 months
- Children with progressive or neurodegenerative disorders; underlying known genetic or chromosomal disorders, familial or non-familial syndromes (without known chromosomal or genetic defect)
- Patients with cerebral lesions caused by sickle cell disease or by emboli associated with congenital cardiac lesions
- Patients incapable of voluntary movement or with severe cognitive deficits who cannot follow simple verbal commands
- Typically Developing Children:
- Children with chronic medical disorders or any neurological and /or psychiatric disorder including attention deficit hyperactivity disorder or learning disorder
- Children taking regular medications, including medications for allergies, hormonal oral contraceptives, or over-the-counter medications
- Children born before 36 weeks gestation as estimated by dates, ultrasound or other methods (if a discrepancy exists, then the ultrasound estimation will be taken as definitive)
- Exclusionary criteria for clinical MRI studies:
- Any child with metal objects in the body such as pacemakers, aneurysm clips (metal clips on the wall of a large artery), metallic prostheses, cochlear implants, or shrapnel fragments).
- Any child with permanent tattoos on the eyelids (ferromagnetic iron oxide-based) tattoo pigments can interact with the static magnetic field of an MRI imager.
- Exclusionary criteria for TMS:
- 1\. Children with hearing loss (greater than 15 dB at any individual frequency) in either ear (as evaluated in the Audiology Department, CC, NIH).
Exclusion
Key Trial Info
Start Date :
December 27 2004
Trial Type :
OBSERVATIONAL
End Date :
August 30 2006
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT00100503
Start Date
December 27 2004
End Date
August 30 2006
Last Update
July 2 2017
Active Locations (1)
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1
National Institute of Neurological Disorders and Stroke (NINDS)
Bethesda, Maryland, United States, 20892