Status:
COMPLETED
Pharmacokinetics/Pharmacodynamics (PK/PD) of Cangrelor
Lead Sponsor:
The Medicines Company
Conditions:
Healthy
Eligibility:
All Genders
18-55 years
Phase:
PHASE1
Brief Summary
The purposes of this study are to: * Evaluate the tolerability of two cangrelor regimens. * Compare the PD of cangrelor regimens with oral clopidogrel.
Detailed Description
The purposes of this study are: * To evaluate the tolerability of two cangrelor regimens of bolus plus infusion (A and B). * To characterize the pharmacokinetics of Cangrelor (A and B). * To compare ...
Eligibility Criteria
Inclusion
- Provide written informed consent before initiation of any study related procedures.
- Age 18 - 55 years
- Normal findings on physical examination.
- A normal 12-lead ECG and normal vital signs (blood pressure, heart rate), unless any abnormality was considered clinically irrelevant by the investigator.
- Normal laboratory and hematology values unless the investigator considered an abnormality to be clinically irrelevant.
- Negative test for pregnancy as determined by urinary b-HCG prior to the administration of study drug for all females of child-bearing potential.
- Body Mass Index (BMI) between 20 and 25 kg/m2 based on actual body weight.
Exclusion
- A history of or presence of renal, hepatic, neurological, hematological, gastrointestinal, or psychiatric disease or other condition known to interfere with the absorption, distribution, metabolism or excretion of drugs.
- Hypersensitivity to clopidogrel or cangrelor (or the excipients therein).
- Symptoms of a clinically significant illness, or surgery or trauma within 3 months prior to screening.
- Donation of blood or plasma totaling more than 500 mL within the 3 months preceeding the study.
- A significant history of alcohol or drug abuse, a positive urine drug screen, tobacco use within the 3 months preceding enrollment, or alcohol ingestion within 48 hours of dosing.
- A history of hepatitis or human immunodeficiency virus (HIV) or exposure thereto.
- Use of any prescribed medications in the 2 weeks prior to dosing, any aspirin or naproxen-containing medication within 2 weeks of dosing, use of acetaminophen within 24 hours or ibuprofen, vitamins or dietary supplements within 48 hours of dosing (oral contraceptives are permitted).
- Personal or family history of coagulation or bleeding disorders, or reasonable suspicion of vascular malformations, including aneurysms; history of important bleeding, (i.e. hematemesis, rectal bleeding, melena, severe or recurrent epistaxis, hemoptysis or intracranial hemorrhage), history of head injury or intracerebral disease, or recent or planned spinal or epidural puncture.
- Significant epigastric pain or "indigestion", either chronically or within 4 weeks prior to screening.
- Diagnosed hypertension, or supine blood pressure at or above 150/90 mmHG or less than 100/50 mmHg at screening.
- Participation in any clinical study with an investigational new drug in the 3 months prior to dosing in the study or participation in a study with a new formulation of a marketed drug in the previous 3 months.
- Anemia or thrombocytopenia (values on screening hematology less than the reporting laboratory's lower limit of normal).
- Any other characteristic or condition which, in the opinion of the investigator, makes participation in this study inappropriate.
Key Trial Info
Start Date :
March 1 2005
Trial Type :
INTERVENTIONAL
End Date :
May 1 2005
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT00102674
Start Date
March 1 2005
End Date
May 1 2005
Last Update
August 16 2011
Active Locations (1)
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1
University of Kentucky
Lexington, Kentucky, United States, 40536