Status:
SUSPENDED
Neuromodulation and Language Acquisition (Stage Ib)
Lead Sponsor:
University Hospital Muenster
Conditions:
Healthy
Eligibility:
All Genders
20-35 years
Phase:
PHASE4
Brief Summary
The purpose of this study is to determine whether rivastigmine or pramipexol are effective in boosting semantic language acquisition in healthy subjects.
Detailed Description
Our prior work shows that d-amphetamine and the dopamine precursor levodopa markedly improve word learning success in healthy subjects. In this randomized, placebo-controlled, double-blind clinical tr...
Eligibility Criteria
Inclusion
- Healthy subjects
- 20-35 years old
- Right handedness
- Left language dominance (as assessed by functional transcranial Doppler ultrasonography \[fTCD\])
Exclusion
- Neurological/psychiatric/metabolic/cardiac disorders
- Asthma
- Known allergic reactions to one of the experimental drugs
- Other drugs affecting the central nervous system
- Leisure drug ingestion during the past 4 weeks (urine test)
- Smoking cessation during the past 2 weeks
- \> 6 cups of coffee or energy drinks per day
- \> 10 cigarettes per day
- \> 50 grams of alcohol per day
Key Trial Info
Start Date :
January 1 2005
Trial Type :
INTERVENTIONAL
End Date :
June 1 2006
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT00102856
Start Date
January 1 2005
End Date
June 1 2006
Last Update
June 24 2010
Active Locations (1)
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1
Dept. of Neurology, University Hospital Muenster
Münster, North Rhine-Westphalia, Germany, 48129