Status:
COMPLETED
Dopaminergic Enhancement of Learning and Memory in Aphasia
Lead Sponsor:
University Hospital Muenster
Collaborating Sponsors:
German Federal Ministry of Education and Research
Conditions:
Cerebrovascular Accident
Aphasia
Eligibility:
All Genders
18-75 years
Phase:
PHASE4
Brief Summary
The purpose of this study is to determine whether levodopa, in combination with a high frequency language training, is effective in boosting naming performance in patients with aphasia.
Detailed Description
Our prior work shows that d-amphetamine and the dopamine precursor levodopa markedly improve word learning success in healthy subjects. In this randomized, placebo-controlled, double-blind clinical tr...
Eligibility Criteria
Inclusion
- Inclusion Criteria for patients with aphasia:
- Unilateral cerebrovascular accident (stroke) in the territory of the arteria media
- Time post onset: \> 6 months
- Aphasia with anomia
- Age between 18-75 years
- Premorbid right-handedness
- Primary language: German
- Exclusion Criteria for patients and healthy controls:
- Known allergy to levodopa or tartrazine
- History of medication/drug abuse
- Acute nicotine withdrawal or \> 15 cigarettes per day
- \> 6 cups/glasses of coffee, caffeine drinks or energy drinks per day
- \> 50 grams of alcohol per day
- Severe hypertonia (systole \>180 mm Hg)
- Severe arteriosclerosis
- Diabetes, asthma, or glaucoma
- Severe hearing disability
- Evidence for severe hippocampal damage
- Premorbid depression or psychosis
- Medication with dopamine agonists or antagonists
- Parkinsonian symptoms
- Changes in anticonvulsive medication during the week prior to study enrollment
Exclusion
Key Trial Info
Start Date :
January 1 2005
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2008
Estimated Enrollment :
12 Patients enrolled
Trial Details
Trial ID
NCT00102869
Start Date
January 1 2005
End Date
December 1 2008
Last Update
October 7 2013
Active Locations (1)
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1
Dept. of Neurology, University Hospital Muenster
Münster, North Rhine-Westphalia, Germany, 48129