Status:
COMPLETED
Genetic Factors That Influence Chronic Obstructive Pulmonary Disease in Hispanics
Lead Sponsor:
University of Pittsburgh
Collaborating Sponsors:
National Heart, Lung, and Blood Institute (NHLBI)
Conditions:
Pulmonary Disease, Chronic Obstructive
Lung Diseases, Obstructive
Eligibility:
All Genders
21-65 years
Brief Summary
The purpose of this study is to examine genetic factors that influence the development of chronic obstructive pulmonary disease (COPD) in Hispanics, a minority group at high risk for the disease.
Detailed Description
DESIGN NARRATIVE: This study will concentrate on a genetically isolated Hispanic population with a high prevalence of COPD living in the Central Valley of Costa Rica. Nine hundred individuals from de...
Eligibility Criteria
Inclusion
- COPD
- Reduced FEV1 after administration of bronchodilator (less than or equal to 60% of predicted value)
- At least six great-grandparents born in the Central Valley of Costa Rica
- At least one sibling with a history of smoking (10 or more packs per year)
Exclusion
- Chronic respiratory disorder other than COPD (as determined by a questionnaire and high-resolution CT chest scan)
- Severe alpha 1-antitrypsin deficiency
Key Trial Info
Start Date :
February 1 2005
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
January 1 2010
Estimated Enrollment :
679 Patients enrolled
Trial Details
Trial ID
NCT00106470
Start Date
February 1 2005
End Date
January 1 2010
Last Update
December 17 2012
Active Locations (1)
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1
Hospital Nacional de Niños
San José, Costa Rica