Status:
COMPLETED
Genetic Research in Schizophrenia Using DNA Markers and Clinical Phenotypes
Lead Sponsor:
VA Office of Research and Development
Conditions:
Schizophrenia
Eligibility:
All Genders
1-79 years
Brief Summary
Schizophrenia has long been known to be an illness with significant evidence for a genetic predisposition. The purpose of this study is to determine the genetic abnormalities that cause childhood and ...
Detailed Description
It is known from genetic linkage and gene expression studies that the alpha 7 nicotinic receptor gene is abnormally expressed in people with schizophrenia. The immediate objectives of this proposal su...
Eligibility Criteria
Inclusion
- Individuals thought to have schizophrenia or schizoaffective disorder, be the parent of such an individual, or be in the matched control group of unrelated individuals not thought to have schizophrenia or schizoaffective disorder
Exclusion
- Unable to give informed consent;
- Psychotic disorder judged to be secondary to substance abuse, psychotic disorder that appears to be secondary to a known medical or neurological disorder, or severe mental retardation
Key Trial Info
Start Date :
January 1 2004
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 1 2008
Estimated Enrollment :
538 Patients enrolled
Trial Details
Trial ID
NCT00108303
Start Date
January 1 2004
End Date
December 1 2008
Last Update
January 7 2016
Active Locations (1)
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1
VA Eastern Colorado Health Care System, Denver
Denver, Colorado, United States, 80220