Status:
COMPLETED
Effects of Insulin Sensitizers in Subjects With Impaired Glucose Tolerance
Lead Sponsor:
US Department of Veterans Affairs
Conditions:
Glucose Metabolism Disorders
Diabetes
Eligibility:
All Genders
35-65 years
Phase:
PHASE4
Brief Summary
Subjects with impaired glucose tolerance will be randomized to receive pioglitazone or metformin for 10 weeks. Measurements of insulin sensitivity, body composition, glucose tolerance, and muscle lipi...
Detailed Description
The progression to type 2 diabetes represents an evolution, which results from a vicious cycle where both glucotoxicity and lipotoxicity act to reduce insulin secretion and insulin action. Lipotoxicit...
Eligibility Criteria
Inclusion
- Impaired glucose tolerance
- Body mass index (BMI) of 28-38
Exclusion
- Heart disease
- Renal disease
- Liver disease
Key Trial Info
Start Date :
January 1 2004
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2007
Estimated Enrollment :
48 Patients enrolled
Trial Details
Trial ID
NCT00108615
Start Date
January 1 2004
End Date
December 1 2007
Last Update
April 25 2008
Active Locations (1)
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1
Central Arkansas Veterans HCS
Little Rock, Arkansas, United States, 72205