Status:
COMPLETED
Siblings With Ischemic Stroke Study
Lead Sponsor:
Mayo Clinic
Collaborating Sponsors:
National Institute of Neurological Disorders and Stroke (NINDS)
Conditions:
Stroke
Eligibility:
All Genders
18+ years
Brief Summary
The purpose of this study is to find the genes that increase the risk of developing an ischemic stroke using DNA samples collected from concordant (stroke-affected) sibling pairs.
Detailed Description
Stroke is the third leading cause of death in the United States and a leading cause of acquired disability in adults. Each year, about 700,000 people experience stroke in the country. Ischemic stroke,...
Eligibility Criteria
Inclusion
- Subject diagnosed by a study neurologist as having had a symptomatic ischemic stroke in the past.
- Head Computed Tomography (CT) or Magnetic Resonance Imaging (MRI) done within 7 days of symptom onset confirms absence of etiology other than ischemic stroke.
- Subject reports having at least one living sibling with a stroke.
- Subject is 18 years of age or older.
Exclusion
- The index ischemic stroke occurred within 48 hours after a cardiovascular or cerebrovascular procedure.
- The index ischemic stroke occurred within 60 days after a non-traumatic subarachnoid hemorrhage.
- The subject has brain biopsy-proven central nervous system vasculitis.
- The subject is known to have any one of the following genetic disorders: CADASIL (Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy), Fabry's disease, homocystinuria, MELAS (Mitochondrial myopathy, Encephalopathy, Lactic Acidosis, Stroke), or sickle cell anemia.
- The subject has a mechanical aortic valve or mechanical mitral valve.
- The subject had untreated or actively treated bacterial endocarditis at the time of the index ischemic stroke.
Key Trial Info
Start Date :
December 1 2000
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
June 1 2011
Estimated Enrollment :
900 Patients enrolled
Trial Details
Trial ID
NCT00108940
Start Date
December 1 2000
End Date
June 1 2011
Last Update
September 27 2011
Active Locations (32)
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1
University of South Alabama
Mobile, Alabama, United States, 36617
2
Mayo Clinic Arizona
Scottsdale, Arizona, United States, 85054
3
East Bay Region Assoc.
Berkeley, California, United States, 94705
4
Scripps Clinic
La Jolla, California, United States, 92039