Status:
UNKNOWN
Dopaminergic Enhancement of Learning and Memory in Healthy Adults and Patients With Dyslexia
Lead Sponsor:
University Hospital Muenster
Conditions:
Dyslexia
Eligibility:
MALE
18-35 years
Phase:
PHASE4
Brief Summary
This study aims to determine whether levodopa, in combination with a high frequency training of (grammatical) rules, is effective in boosting learning success in healthy subjects and whether this kind...
Detailed Description
Prior work by our group shows that d-amphetamine and the dopamine precursor levodopa markedly improve word learning success in healthy subjects. In this randomized, placebo-controlled, double-blind tr...
Eligibility Criteria
Inclusion
- Right-handedness
- Age between 18-35 years
- Primary language: German
Exclusion
- Known allergy to levodopa or tetrazine
- History of medication/drug abuse
- Acute nicotine withdrawal or \> 10 cigarettes per day
- \>6 cups/glasses of coffee, caffeine drinks or energy drinks per day
- \>50 grams of alcohol per day
- Hypertonia
- Arteriosclerosis
- Diabetes, asthma, or glaucoma
- Psychiatric disease
- Neurologic disease
- Other medication
Key Trial Info
Start Date :
January 1 2005
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
October 1 2015
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT00111371
Start Date
January 1 2005
End Date
October 1 2015
Last Update
December 5 2014
Active Locations (1)
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1
Dept. of Neurology, University Hospital of Muenster
Münster, North Rhine-Westphalia, Germany, 48129