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Status:

COMPLETED

Depsipeptide (Romidepsin) in Treating Patients With Metastatic or Unresectable Soft Tissue Sarcoma

Lead Sponsor:

National Cancer Institute (NCI)

Conditions:

Adult Alveolar Soft-part Sarcoma

Adult Angiosarcoma

Eligibility:

All Genders

18+ years

Phase:

PHASE2

Brief Summary

This phase II trial studies how well depsipeptide (romidepsin) works in treating patients with metastatic or unresectable soft tissue sarcoma. Drugs used in chemotherapy, such as depsipeptide, work in...

Detailed Description

PRIMARY OBJECTIVES: I. To estimate the response rates of metastatic or unresectable soft tissue sarcomas to single-agent depsipeptide. II. To estimate the time to progression of metastatic or unrese...

Eligibility Criteria

Inclusion

  • Histologically or cytologically confirmed soft tissue sarcoma (STS), including, but not limited to, the following histologies:
  • Gastrointestinal stromal tumors (GIST)
  • Refractory to imatinib mesylate
  • Desmoplastic small round cell tumors
  • Clear cell sarcoma
  • Extraskeletal osteosarcoma\*
  • Extraskeletal Ewing's sarcoma\*
  • Extraskeletal (myxoid) chondrosarcoma\*
  • Secondary STS (e.g., radiation-induced STS or neurofibrosarcoma due to neurofibromatosis) allowed
  • Metastatic or unresectable disease
  • No standard curative therapy exists
  • Patients with GIST must have received and progressed on imatinib mesylate
  • Measurable disease, defined as ≥ 1 unidimensionally measurable lesion ≥ 20 mm by conventional techniques OR ≥ 10 mm by spiral CT scan
  • No known brain metastases
  • Performance status - Eastern Cooperative Oncology Group (ECOG) 0-2
  • Performance status - Karnofsky 50-100%
  • More than 3 months
  • White blood cells (WBC) ⥠3,000/mm\^3
  • Absolute neutrophil count ≥ 1,500/mm\^3
  • Platelet count ≥ 100,000/mm\^3
  • Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ⤠2.5 times upper limit of normal (ULN)
  • Bilirubin normal
  • Creatinine \< 1.5 times ULN
  • Creatinine clearance ≥ 60 mL/min
  • QTc ≤ 480 msec

Exclusion

  • No cardiac abnormalities (e.g., congenital long QT syndrome)
  • No myocardial infarction within the past year
  • No history of coronary artery disease (e.g., angina Canadian Class II-IV or positive stress imaging study)
  • No cardiac ischemia (ST depression \>2 mm) by electrocardiogram (ECG)
  • No New York Heart Association Class II-IV congestive heart failure
  • Ejection fraction \> 50% by multi gated acquisition scan (MUGA) scan or echocardiogram
  • No history of sustained ventricular tachycardia, ventricular fibrillation, Torsades de Pointes, or cardiac arrest unless controlled by an automatic implantable cardioverter defibrillator
  • No hypertrophic or restrictive cardiomyopathy from prior treatment or other causes
  • No significant left ventricular hypertrophy
  • No uncontrolled hypertension (i.e., blood pressure ≥ 160/95 mm Hg)
  • No cardiac arrhythmia requiring anti-arrhythmic medication
  • Beta blocker or calcium channel blocker allowed
  • Patients on digitalis that cannot be discontinued not allowed
  • No Mobitz II second degree block without a pacemaker (first degree or Mobitz I second degree block, bradyarrhythmias, or sick sinus syndrome require Holter monitoring and evaluation by cardiology)
  • No uncontrolled dysrhythmia
  • No poorly controlled angina
  • No other cardiac disease
  • No history of allergic reaction attributed to compounds of similar chemical or biological composition to FR901228
  • No ongoing or active infection
  • No iatrogenic immune deficiency or immune deficiency secondary to an underlying disorder
  • Not pregnant or nursing
  • Negative pregnancy test
  • Fertile patients must use effective contraception
  • Potassium ≥ 4.0 mmol/L
  • Magnesium ≥ 2.0 mg/dL
  • No other uncontrolled illness
  • No psychiatric illness or social situation that would preclude study compliance
  • No concurrent anticancer biologic agents
  • No more than 1 prior chemotherapy regimen for sarcoma
  • Adjuvant chemotherapy preceding disease relapse is considered 1 prior chemotherapy regimen
  • Patients with GIST may have received up to 3 prior chemotherapy regimens comprising imatinib mesylate and/or sunitinib malate provided no other chemotherapy agents were used
  • No prior FR901228 (depsipeptide)
  • At least 4 weeks since prior chemotherapy (6 weeks for nitrosoureas or mitomycin)
  • No prior cumulative doxorubicin dose \> 500 mg/m\^2
  • No other concurrent anticancer chemotherapy
  • At least 4 weeks since prior radiotherapy
  • No concurrent anticancer radiotherapy
  • At least 4 weeks since prior surgery
  • No prior organ transplantation
  • Recovered from all prior therapy
  • No concurrent medications that cause QTc prolongation
  • No concurrent combination highly active anti-retroviral therapy for HIV-positive patients
  • No other concurrent drugs known to have histone deacetylase inhibitor activity (e.g., sodium valproate)
  • No other concurrent investigational agents
  • No other concurrent anticancer agents

Key Trial Info

Start Date :

January 7 2005

Trial Type :

INTERVENTIONAL

Allocation :

ACTUAL

End Date :

October 23 2008

Estimated Enrollment :

40 Patients enrolled

Trial Details

Trial ID

NCT00112463

Start Date

January 7 2005

End Date

October 23 2008

Last Update

June 14 2017

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