Status:
COMPLETED
Urban Environmental Factors and Childhood Asthma
Lead Sponsor:
National Institute of Allergy and Infectious Diseases (NIAID)
Collaborating Sponsors:
Inner-City Asthma Consortium
Rho Federal Systems Division, Inc.
Conditions:
Asthma
Allergy
Eligibility:
All Genders
Brief Summary
Minority children who grow up in poor urban neighborhoods have the highest rates of asthma, and also experience greater morbidity from acute exacerbations of this disease. The aim of this study is to ...
Detailed Description
The purpose of this study is to determine the way environmental factors (like the components of inner-city household dust) affect immune system development and symptoms of asthma in inner city childre...
Eligibility Criteria
Inclusion
- Inclusion Criteria for Mothers:
- Plan to give birth at the study hospital
- Have asthma, hay fever, or eczema (or infant's father has any of these diseases)
- Currently reside in a pre-selected area containing at least 20% of households below the U.S. government poverty level
- At least 34 weeks pregnant at time of delivery
- Willing to allow an umbilical cord blood specimen to be obtained from her infant
- Willing to comply with all study requirements
- Have access to a phone
- Speak English. Spanish-speaking participants enrolled at sites with Spanish-speaking staff are also eligible.
- Exclusion Criteria for Mothers:
- HIV infected at the time of delivery
- Plan to move out of the geographic area during the study
- Exclusion Criteria for Infants:
- Respiratory distress requiring intubation and ventilation for 4 hours or more
- Respiratory distress requiring either supplemental oxygen or continuous positive airway pressure (CPAP) for 4 days or more
- Pneumonia requiring antibiotic treatment for 1 week or more
- Significant congenital abnormality
- Received palivizumab for respiratory syncytial virus prophylaxis
Exclusion
Key Trial Info
Start Date :
February 2 2005
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
August 31 2024
Estimated Enrollment :
560 Patients enrolled
Trial Details
Trial ID
NCT00114881
Start Date
February 2 2005
End Date
August 31 2024
Last Update
July 18 2025
Active Locations (4)
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1
Pediatric Clinical Research Unit, Johns Hopkins University
Baltimore, Maryland, United States, 21287
2
Boston Medical Center
Boston, Massachusetts, United States, 02118
3
Saint Louis Children's Hospital
St Louis, Missouri, United States, 63110
4
Columbia University Medical Center
New York, New York, United States, 10032