Status:
COMPLETED
The Contribution of Endothelin to Vasomotor Function in Diseased Coronary Arteries
Lead Sponsor:
Brigham and Women's Hospital
Conditions:
Atherosclerosis, Coronary
Eligibility:
All Genders
18-75 years
Phase:
NA
Brief Summary
The purpose of the study is to assess the importance of a substance called endothelin. Endothelin is produced by coronary arteries. This study examines this substance to determine whether it has an ef...
Detailed Description
There are many substances that influence the diameter of the coronary artery and a number of these are actually released by the lining of the coronary arteries (referred to as the endothelium). Over t...
Eligibility Criteria
Inclusion
- Adult men and women between the ages of 18 to 75 years will be enrolled and categorized into one of 4 groups. The categories are defined below:
- Control patients characterized by chest pain and angiographically normal coronary arteries.
- Chronic stable angina patients who describe a history of exertional chest pain which is unchanged in frequency over the preceding month, and who have at least a 70% stenosis in a coronary artery.
- Unstable angina patients who describe chest pain at rest or with minimal exertion over the preceding 2 weeks, and who have an identifiable culprit stenosis in a coronary artery.
- Cardiac transplant recipients who are undergoing routine annual surveillance cardiac catheterization.
Exclusion
- Patients with the following will be excluded from the study:
- Angiographic exclusion criteria: \*Left main coronary artery disease or severe triple vessel disease; \*Unstable angina without any identifiable culprit lesion.
- Severe left ventricular dysfunction (ejection fraction \< 40%) or clinical cardiac failure.
- Nitroglycerin required in the preceding 4 hours prior to the investigation.
- Severe renal, hepatic or hematologic abnormalities.
- Inability to obtain written informed consent.
Key Trial Info
Start Date :
November 1 1998
Trial Type :
INTERVENTIONAL
End Date :
April 1 2007
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT00115583
Start Date
November 1 1998
End Date
April 1 2007
Last Update
December 9 2016
Active Locations (1)
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1
Brigham and Womens Hospital
Boston, Massachusetts, United States, 02115