Status:

COMPLETED

Systemic Immunosuppressive Therapy for Eye Diseases (SITE) Cohort Study

Lead Sponsor:

National Eye Institute (NEI)

Conditions:

Uveitis

Cancer

Eligibility:

All Genders

Brief Summary

This study will evaluate whether therapy that suppresses the immune system given to treat inflammatory diseases of the eye is associated with a greater risk of death and of cancer. Inflammatory diseas...

Detailed Description

BACKGROUND: Ocular inflammatory diseases, including uveitis, scleritis, and mucous membrane pemphigoid, are major blinding eye diseases. For some patients, corticosteroid therapy is insufficient to c...

Eligibility Criteria

Inclusion

  • INCLUSION CRITERIA: Patients with the following diagnoses will be included:
  • Anterior uveitis;
  • Intermediate uveitis;
  • Posterior uveitis or panuveitis;
  • Scleritis;
  • Mucous membrane pemphigoid;
  • Other non-infectious ocular inflammatory disease.
  • EXCLUSION CRITERIA:
  • No ocular inflammatory disease;
  • Infectious ocular inflammatory disease (e.g. toxoplasmic retinitis, endophthalmitis, viral retinitis), unless the infectious uveitis followed treatment for a non-infectious ocular inflammatory disease.

Exclusion

    Key Trial Info

    Start Date :

    June 16 2005

    Trial Type :

    OBSERVATIONAL

    End Date :

    April 21 2008

    Estimated Enrollment :

    6300 Patients enrolled

    Trial Details

    Trial ID

    NCT00116090

    Start Date

    June 16 2005

    End Date

    April 21 2008

    Last Update

    July 2 2017

    Active Locations (4)

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    Page 1 of 1 (4 locations)

    1

    Johns Hopkins University

    Baltimore, Maryland, United States, 21205

    2

    National Institutes of Health Clinical Center, 9000 Rockville Pike

    Bethesda, Maryland, United States, 20892

    3

    Massachusetts Eye and Ear Infirmary

    Boston, Massachusetts, United States, 02114-3096

    4

    Oregon Health Sciences University

    Portland, Oregon, United States, 97201-3098