Status:
COMPLETED
Exercise and Weight Loss for Improving Mobility in Older Adults Who Are Obese
Lead Sponsor:
Wake Forest University Health Sciences
Collaborating Sponsors:
National Heart, Lung, and Blood Institute (NHLBI)
Conditions:
Cardiovascular Diseases
Heart Diseases
Eligibility:
All Genders
60-79 years
Phase:
NA
Brief Summary
To test the effects of exercise and weight loss on mobility disability of older overweight/obese men and women who have evidence of cardiovascular disease or the metabolic syndrome.
Detailed Description
BACKGROUND: Older adults make up the fastest growing segment of our population. It is estimated that by the year 2030, elderly people will make up 22% of the United States population. A large portion...
Eligibility Criteria
Inclusion
- Currently living in one of the counties surrounding Winston-Salem, NC
- Sedentary (engages in fewer than 30 minutes of moderate structured physical activity for at least 10 minutes at a time each week)
- Overweight or obese, as defined by a body mass index (BMI) greater than 25
- Fasting glucose level less than 140
- Documented evidence of an MI, PCTA, chronic stable angina, or cardiovascular surgery (coronary artery or valvular heart disease) within the 6 months prior to study entry or an ATP III diagnosis of the metabolic syndrome
- Disability defined as self-reported difficulty with walking ¼ mile, climbing stairs, lifting and carrying groceries, or performing other household chores such as cleaning and yard work
- Does not plan to move out of the county of residence for the duration of the study
Exclusion
- Diagnosis of bipolar depression or schizophrenia (defined as self-reported treatment for these conditions)
- Currently receiving lithium or neuroleptics
- Evidence of unstable angina, symptomatic congestive heart failure, or exercise-induced complex ventricular arrhythmias
- Resting blood pressure greater than 160/100 mmHg
- Diagnosis of any of the following: Parkinson's disease; chronic liver disease (cirrhosis, chronic hepatitis, etc.); systemic rheumatic condition (rheumatoid arthritis, psoriatic arthritis, Reiter's disease, systemic lupus erythematosus, etc.); end stage renal disease; or other systemic diseases or abnormal laboratory values which would preclude participants from safely participating in the protocol or impair their ability to complete the study
- Actively being treated for cancer (other than non-melanotic skin cancer)
- Significant visual or hearing impairment that cannot be corrected and results in the inability to use the telephone or hear normal conversation
- Currently participating in or planning to participate in another medical intervention study
- Current alcohol abuse disorder or consumes more than 21 alcoholic drinks per week
- Unable to walk without assistance
- Unable to speak or read English
- Judged by the clinic staff to be unsuitable for the trial for any reason
Key Trial Info
Start Date :
August 1 2005
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 1 2011
Estimated Enrollment :
288 Patients enrolled
Trial Details
Trial ID
NCT00119795
Start Date
August 1 2005
End Date
April 1 2011
Last Update
August 15 2018
Active Locations (3)
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1
Guilford County, North Carolina Cooperative Extension Center
Greensboro, North Carolina, United States, 27405
2
Davidson County Coopertive Extension
Lexington, North Carolina, United States, 27292
3
Forsyth County Cooperative Extension Center
Winston-Salem, North Carolina, United States, 27105