Status:
COMPLETED
The Effect of Fasudil on Vascular Function in Humans
Lead Sponsor:
Brigham and Women's Hospital
Conditions:
Atherosclerosis
Hypercholesterolemia
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
The purpose of the study is to evaluate how the rho kinase inhibitor, fasudil, affects vascular function in patients with atherosclerosis and hyperlipidemia.
Eligibility Criteria
Inclusion
- Coronary artery disease
- Hyperlipidemia -OR-
- Healthy adults
Exclusion
- Unstable angina, myocardial infarction or revascularization within 3 months
- Symptomatic heart failure
- Creatinine \> 3.0 mg/dl
- Liver enzymes \> 3X upper limit of normal
- Chronic hypoxia
- Significant anemia
- Chronic inflammatory disease
- Pregnancy
- Willing to withdraw statins for duration of study
Key Trial Info
Start Date :
June 1 2002
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
January 1 2007
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT00120718
Start Date
June 1 2002
End Date
January 1 2007
Last Update
September 30 2008
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Brigham and Women's Hospital
Boston, Massachusetts, United States, 02115