Status:
COMPLETED
The CLARICOR Trial: Effect of Clarithromycin on Mortality and Morbidity in Patients With Ischemic Heart Disease
Lead Sponsor:
Copenhagen Trial Unit, Center for Clinical Intervention Research
Collaborating Sponsors:
Danish Heart Foundation
Copenhagen Hospital Corporation
Conditions:
Heart Disease
Cardiovascular Disease
Eligibility:
All Genders
18-84 years
Phase:
PHASE3
Brief Summary
A growing body of evidence links Chlamydia pneumoniae to the progression of coronary heart disease. The purpose of this study is to determine the positive and negative effect of 14 days treatment with...
Detailed Description
Basic science suggests a fundamental role for inflammation in mediating all stages of coronary heart disease (CHD), and a large number of clinical studies have reported an association between markers ...
Eligibility Criteria
Inclusion
- patients aged 18 to 85 years and
- previous acute myocardial infarction (AMI) or
- previous or present angina pectoris and
- signed informed concent
Exclusion
- AMI or unstable angina pectoris within the last three months
- revascularisation (PTCA or CABG) within the preceding six months
- severe heart failure (New York Heart Association (NYHA) functional class IV)
- known impaired renal or hepatic function
- active malignancy
- intolerance to macrolides
- treatment with methylxanthines, carbamazepine, cisapride, astemizole, terfenadine, or coumarin anticoagulants
- earlier inclusion in the CLARICOR Trial or participation in another drug trial within four weeks
- participation in other clinical trials within one month before this trial
- individuals incapable of managing own affairs or not able to sign written consent
- lack of written consent
- women of childbearing age not using reliable contraceptives
- breast feeding women
Key Trial Info
Start Date :
October 1 1999
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 1 2002
Estimated Enrollment :
4372 Patients enrolled
Trial Details
Trial ID
NCT00121550
Start Date
October 1 1999
End Date
September 1 2002
Last Update
August 11 2016
Active Locations (6)
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1
Copenhagen Trial Unit, Center for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9
Copenhagen, Denmark, 2100
2
H:S Rigshospitalet
Copenhagen, Denmark, 2100
3
H:S Amager Hospital
Copenhagen, Denmark, 2300
4
H:S Bispebjerg Hospital
Copenhagen, Denmark, 2400