Status:
COMPLETED
Fish Oil for the Treatment of Depression in Patients With Multiple Sclerosis
Lead Sponsor:
Oregon Health and Science University
Collaborating Sponsors:
National Center for Complementary and Integrative Health (NCCIH)
Conditions:
Multiple Sclerosis
Depression
Eligibility:
All Genders
18-85 years
Phase:
PHASE1
PHASE2
Brief Summary
This study will determine whether fish oil can reduce depression in people with multiple sclerosis (MS) who are mild to moderately depressed and are currently taking antidepressant medication. Study ...
Detailed Description
Depression occurs in 50% to 60% of all individuals with MS. Evidence suggests that the omega-3 fatty acids in fish oil supplements can significantly reduce depression with a low risk of side effects. ...
Eligibility Criteria
Inclusion
- Diagnosis of relapsing-remitting MS
- Diagnosis of depressive disorder
- Score between 11 and 30 on the Montgomery-Asberg Depression Rating Scale (MADRS)
- Score of 25 or greater on the Mini-Mental State Examination (MMSE)
- Currently taking antidepressant medication for at least 3 months prior to study entry
Exclusion
- Currently taking fatty acid supplements
- Consume more than 6 oz of fish per week within 1 month prior to study entry
- Severe depression
- Suicidal thoughts
- Other psychological disorders
- Currently taking more than two types of antidepressants
- Any serious medical condition that would interfere with the study
- Worsening of MS symptoms or corticosteroid treatment within 1 month prior to study entry
- Current enrollment in another fish oil study
- Pregnancy
Key Trial Info
Start Date :
July 1 2005
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2009
Estimated Enrollment :
39 Patients enrolled
Trial Details
Trial ID
NCT00122954
Start Date
July 1 2005
End Date
June 1 2009
Last Update
June 8 2017
Active Locations (1)
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1
Oregon Health and Science University
Portland, Oregon, United States, 97239