Status:

COMPLETED

Rapamycin Use in Calcineurin Inhibitor (CNI)-Free Immunosuppression for Stabilization/Improvement of Renal Function After Heart Transplantation

Lead Sponsor:

Heidelberg University

Collaborating Sponsors:

Wyeth is now a wholly owned subsidiary of Pfizer

Conditions:

Heart Transplantation

Renal Failure

Eligibility:

All Genders

18+ years

Phase:

PHASE4

Brief Summary

Clinical Problem: Renal insufficiency after heart transplantation caused by cyclosporine medication was addressed. Current therapeutic approaches include cyclosporine reduction or discontinuation. It ...

Detailed Description

Clinical Problem: Renal insufficiency after heart transplantation caused by cyclosporine medication was addressed. Current therapeutic approaches include cyclosporine reduction or discontinuation. It ...

Eligibility Criteria

Inclusion

  • Heart transplantation (\> 6 months post-operation)
  • Renal failure (serum creatinine stably \> 1.7 mg/dl
  • Cyclosporine trough blood level \< 110 ng/ml

Exclusion

  • \< 18 years of age
  • Rapamycin intolerability
  • Active infection
  • Pregnancy, breast feeding
  • Major elective surgery planned in study period
  • Thrombopenia \< 100,000/ml

Key Trial Info

Start Date :

October 1 2003

Trial Type :

INTERVENTIONAL

End Date :

April 1 2005

Estimated Enrollment :

40 Patients enrolled

Trial Details

Trial ID

NCT00123331

Start Date

October 1 2003

End Date

April 1 2005

Last Update

August 2 2005

Active Locations (1)

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1

Medizinische Universitätsklinik, Kardiologie

Heidelberg, Germany, D-69115