Status:
COMPLETED
Intravenous Magnesium Sulfate in Aneurysmal Subarachnoid Haemorrhage (IMASH)
Lead Sponsor:
Chinese University of Hong Kong
Conditions:
Subarachnoid Hemorrhage
Eligibility:
All Genders
18-80 years
Phase:
PHASE3
Brief Summary
The IMASH trial is a simple, randomized, double-blinded, placebo-controlled, multi-center trial to answer the question: "Does intravenous magnesium sulfate improve clinical outcome after aneurysmal su...
Detailed Description
Vasospasm worsen outcome in patients with aneurysmal subarachnoid hemorrhage (ASAH). Magnesium is known to dilate cerebral arteries and to block N-methyl-D-aspartate receptors in the injured neurons....
Eligibility Criteria
Inclusion
- ASAH (as indicated by CT scan or lumbar puncture and an intracranial aneurysm confirmed by computer tomographic or conventional angiography)
- Within 48 hrs of ictus (hemorrhage event)
Exclusion
- Pregnancy
- Major renal, hepatic or pulmonary disease
- Major cardiac disease or recent myocardial infarct (\< 6 months)
- Age less than 18 years
- Moribund condition on admission (defined as a patient that is in such a poor clinical condition that further active neurosurgical management would not be anticipated)
Key Trial Info
Start Date :
June 1 2002
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2009
Estimated Enrollment :
327 Patients enrolled
Trial Details
Trial ID
NCT00124150
Start Date
June 1 2002
End Date
June 1 2009
Last Update
December 23 2009
Active Locations (1)
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1
Department of Surgery, The Chinese University of Hong Kong
Hong Kong, China, 852