Status:
COMPLETED
Conservative Versus Liberal Red Cell Transfusion in Myocardial Infarction Trial: The CRIT Pilot
Lead Sponsor:
Medstar Health Research Institute
Collaborating Sponsors:
US Department of Veterans Affairs
Conditions:
Myocardial Infarction
Anemia
Eligibility:
All Genders
21+ years
Phase:
PHASE4
Brief Summary
The purpose of this trial is to determine whether a conservative or a liberal blood transfusion strategy is better for patients with a heart attack and a low blood count.
Detailed Description
The current standard of care for patients with heart attacks is to transfuse red blood cells when the hematocrit (red blood cell count) drops below 30 percent. However, there is little scientific basi...
Eligibility Criteria
Inclusion
- All of the following must be present:
- Acute myocardial infarction with presentation within 72 hours of randomization (acute myocardial infarction is defined as ischemic-type chest discomfort lasting at least 30 minutes associated with creatinine kinase MB (CKMB) or troponin \>upper limit of normal \[ULN\])
- Admission to CCU
- Hematocrit .30 or less
- Written, informed consent
Exclusion
- Inability or unwillingness to receive red cell transfusions
- Active bleeding (overt blood loss accompanied by a decrease in hematocrit of at least 5% in the preceding 12 hours)
- Receipt of red cell transfusion within 7 days of randomization
- Prior severe transfusion reaction
- Pregnancy
- Imminent death
- Decision to provide limited care
- Age \<21
- Participation in another clinical trial in which blood transfusion is a requirement or a component of a primary or secondary endpoint
- Previous participation in the CRIT Pilot
Key Trial Info
Start Date :
April 1 2003
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2011
Estimated Enrollment :
45 Patients enrolled
Trial Details
Trial ID
NCT00126334
Start Date
April 1 2003
End Date
January 1 2011
Last Update
July 21 2011
Active Locations (3)
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1
Washington Hospital Center
Washington D.C., District of Columbia, United States, 20010
2
Washington VA Medical Center
Washington D.C., District of Columbia, United States, 20010
3
Durham VA Medical Center
Durham, North Carolina, United States