Status:
COMPLETED
European Trial of Adjuvant Oral Glucocorticoid Pulse Therapy in Pemphigus
Lead Sponsor:
University Medical Center Groningen
Conditions:
Pemphigus
Eligibility:
All Genders
18+ years
Phase:
PHASE2
PHASE3
Brief Summary
By this study, the investigators want to test if the value of adjuvant pulse glucocorticoid therapy for pemphigus can be determined by comparing an experimental arm (dexamethasone pulse therapy, predn...
Detailed Description
Pemphigus is a severe chronic dermatological disease which appears to be incurable. Oral glucocorticoid now forms the cornerstone of treatment. From previous uncontrolled studies it has been suggested...
Eligibility Criteria
Inclusion
- New patients with diagnosis of pemphigus vulgaris
Exclusion
- Diagnosis of pemphigus different from vulgaris type
- Current use of adjuvant treatment other than azathioprine. A wash out period of at least 2 weeks is required before inclusion is acceptable.
- Presence of contra-indications for the use of high dose steroids
- No availability for follow-up.
- Concomitant diseases treated with oral steroids.
- Glucocorticoids administered for pemphigus vulgaris longer than two months.
- Presence of contra-indications for the use of azathioprine.
Key Trial Info
Start Date :
January 1 2001
Trial Type :
INTERVENTIONAL
End Date :
April 1 2005
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT00127764
Start Date
January 1 2001
End Date
April 1 2005
Last Update
August 30 2007
Active Locations (1)
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1
Department of Dermatology, University Medical Center Groningen
Groningen, Netherlands, 9713 GZ