Status:
COMPLETED
Effects of Early Statin Treatment After Acute Myocardial Infarction (AMI) in Japanese Patients
Lead Sponsor:
Kumamoto University
Conditions:
Myocardial Infarction
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
Statins have been shown to prevent coronary artery disease and to preserve left ventricular function in dilated cardiomyopathy. The investigators hypothesized that the early use of statins would reduc...
Detailed Description
At least, in Japanese, it was controversial if lipid-lowering therapy to the patients whose total cholesterol levels \<240 mg/dL was needed. Furthermore, in general, a role for early statin therapy in...
Eligibility Criteria
Inclusion
- Clinical diagnosis of acute myocardial infarction
- Serum total cholesterol levels on admission ranges ≥180 mg/dL and \<240 mg/dL
Exclusion
- Age \< 18 years
- Time from symptom onset to admission \> 96 hours
- Use of lipid-lowering agents within the previous 3 months
- Known familial dyslipidemia
- Severe renal failure
- Known hepatic disease
- Signs and symptoms of severe heart failure (Killip class III or IV)
- A scheduled PCI or coronary artery bypass grafting (CABG)
- A history of previous PCI (within 6 months) or CABG (within 3 months)
- The presence of malignant disease
- The presence of allergy to statins.
Key Trial Info
Start Date :
February 1 2002
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 1 2006
Estimated Enrollment :
460 Patients enrolled
Trial Details
Trial ID
NCT00128024
Start Date
February 1 2002
End Date
February 1 2006
Last Update
April 18 2013
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Department of Cardiovascular Medicine, Kumamoto University Hospital
Kumamoto, Kumamoto, Japan, 860-8556