Status:
COMPLETED
The CARO Study - Bioefficacy of Beta-Carotene in Oil and in a Mixed Diet in Healthy Subjects
Lead Sponsor:
Radboud University Medical Center
Collaborating Sponsors:
Dutch Dairy Organization (NZO)
Conditions:
Healthy
Eligibility:
All Genders
18-50 years
Phase:
NA
Brief Summary
A controlled dietary intervention study will be carried out based on the stable isotope method the investigators have developed to quantify both the absorption of beta-carotene and its bioconversion t...
Eligibility Criteria
Inclusion
- Men and women between 18 and 50 years old
- Body mass index (BMI) between 18 and 25 kg/m2
- Willing to consume the controlled diet and not consume other food items
- Willing to consume the cooked meal at the research facility and the bread meals and snacks at home (distributed to the participants)
- Willing to consume the capsules every day
Exclusion
- Hematological diseases and chronic diseases including cancer, renal insufficiency, liver disease, diagnosed gastrointestinal disorders, or surgery of the gastrointestinal tract
- Use of (oral) drugs suspected of interfering with fat-soluble-vitamin absorption
- Smoking
- Excessive alcohol consumption (\>30 g/d)
- Consumption of vitamin or carotenoid supplements 6 weeks before and during the study
- Not too low or high levels of serum beta-carotene and retinol
- Normal hemoglobin, hemocytometry, creatinine, ALAT, alkaline phosphatase, and cholesterol blood values (compared with laboratory references)
- Pregnancy
Key Trial Info
Start Date :
March 1 2003
Trial Type :
INTERVENTIONAL
End Date :
October 1 2003
Estimated Enrollment :
24 Patients enrolled
Trial Details
Trial ID
NCT00128752
Start Date
March 1 2003
End Date
October 1 2003
Last Update
August 29 2005
Active Locations (1)
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1
Radboud University Nijmegen Medical Centre
Nijmegen, Gelderland, Netherlands, 6500HB