Status:
TERMINATED
Sequential HIV Therapy in Treatment Resistant HIV-1 Infected Patients
Lead Sponsor:
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Collaborating Sponsors:
Dutch AIDS Fund
Conditions:
HIV Infections
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
This is an open label, crossover pilot study to explore the safety and efficacy of a rapid cycling regimen of antiretroviral combination therapy in HIV-1 infected patients with virus harboring genotyp...
Detailed Description
Mathematical modeling has suggested that cyclic use of antiretroviral therapy can be an effective strategy in lowering viral load in HIV-1 infected patients when regular triple drug combinations have ...
Eligibility Criteria
Inclusion
- Inclusion Criteria:
- HIV-1 infected patients
- At least 18 years of age
- Males or non-pregnant, non-lactating females
- Documented virological treatment failure on at least 3 classes of antiretroviral drugs
- No adequate antiretroviral therapy possible with currently available antiretroviral agents
- Virological treatment failure is defined as plasma HIV-1 RNA levels \> 5000 while taking at least three different antiretroviral drugs
Exclusion
Key Trial Info
Start Date :
September 1 2005
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2007
Estimated Enrollment :
3 Patients enrolled
Trial Details
Trial ID
NCT00128908
Start Date
September 1 2005
End Date
January 1 2007
Last Update
September 15 2009
Active Locations (1)
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1
HIV Outpatient Clinic, Academic Medical Center
Amsterdam, North Holland, Netherlands, 1105AZ