Status:
UNKNOWN
Functional Genomic Influences on Disease Progression and Outcome in Sepsis
Lead Sponsor:
University of Oxford
Collaborating Sponsors:
Sainsbury Family Charitable Trusts
Wellcome Trust
Conditions:
Pneumonia
Peritonitis
Eligibility:
All Genders
18+ years
Brief Summary
The proposal is aimed at identifying genetic factors that determine the incidence and severity of, and the outcome from life-threatening infections (severe sepsis/septic shock) in patients admitted to...
Detailed Description
The investigators plan to recruit 2,000 cases of community acquired pneumonia (CAP) and 2,000 cases of faecal peritonitis (FP) from 30 UK ICUs and HDUs (members of the UK Critical Care Genomics group ...
Eligibility Criteria
Inclusion
- Patient, or legal representative, is able to give informed consent
- Male or female of 18 years or more
- Patient admitted to ICU/HDU with faecal peritonitis or community acquired pneumonia
Exclusion
- Patient or legal representative is unwilling to consent
- Patient is under the age of 18 years
- Patient is already enrolled in an interventional study
- Patient is immunocompromised
- Patient is pregnant
- There is an advance directive to withhold or withdraw life-sustaining treatment or patient is admitted for palliative care only.
Key Trial Info
Start Date :
September 1 2005
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 1 2017
Estimated Enrollment :
4000 Patients enrolled
Trial Details
Trial ID
NCT00131196
Start Date
September 1 2005
End Date
December 1 2017
Last Update
May 16 2016
Active Locations (50)
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1
Southmead Hospital
Bristol, Avon, United Kingdom, BS10 5NB
2
Royal Berkshire Hospital
Reading, Berkshire, United Kingdom, RG1 5AN
3
Addenbrooke's Hospital
Cambridge, Cambridgeshire, United Kingdom, CB2 2QQ
4
James Cook University Hospital
Middlesbrough, Cleveland, United Kingdom, TS4 3BW