Status:
UNKNOWN
The Effect of Alfa-Adrenergic Receptor Blockade on Insulin-Stimulated Forearm Glucose Uptake and Metabolism in Chronic Heart Failure
Lead Sponsor:
Radboud University Medical Center
Collaborating Sponsors:
ZonMw: The Netherlands Organisation for Health Research and Development
Conditions:
Heart Failure, Congestive
Eligibility:
All Genders
18-75 years
Phase:
NA
Brief Summary
The activity of the sympathetic nervous system seems to influence the uptake (and handling) of glucose by the skeletal muscle of the forearm. Conditions in which sympathetic activity is increased seem...
Eligibility Criteria
Inclusion
- Heart failure of at least New York Heart Association (NYHA) class II
- Left ventricular ejection fraction (LVEF) \<= 40%
- Age 18-75 years
Exclusion
- Alfa-blockers, or beta-blockers with alfa-blocking activity (carvedilol)
- Tricyclic antidepressants
- Warfarin derivatives (acetylic salicylic acid and clopidogrel are allowed)
- Hospitalisation in 6 weeks prior to the study
- Any change in medication in 6 weeks prior to the study
- Unstable angina
- Orthopnoea
- Known chronic disease of the autonomic nervous system
- Diabetes mellitus
- Oedema of the lower extremities, complicating the insertion of a venous catheter in a vein on the foot
Key Trial Info
Start Date :
August 1 2005
Trial Type :
INTERVENTIONAL
End Date :
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT00132106
Start Date
August 1 2005
Last Update
August 31 2007
Active Locations (1)
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1
Radboud University Nijmegen Medical Centre
Nijmegen, Netherlands, 6500 HB