Status:
COMPLETED
Endothelial Modulation for Angiogenic Therapy
Lead Sponsor:
Ottawa Heart Institute Research Corporation
Collaborating Sponsors:
Heart and Stroke Foundation of Ontario
Conditions:
Coronary Artery Disease
Eligibility:
All Genders
18+ years
Phase:
PHASE1
PHASE2
Brief Summary
Coronary artery disease is the single most important killer of Canadians. Despite major advances in therapy, there is still a significant proportion of patients identified with the disease who die of ...
Detailed Description
The EMAT trial tests the hypothesis that the concomitant treatment of chronic endothelial dysfunction in patients undergoing angiogenic therapy can make angiogenesis clinically effective. This is achi...
Eligibility Criteria
Inclusion
- Severe chronic angina
- Multi-vessel coronary artery disease
- Diffusely diseased left anterior descending coronary artery (LAD)
- At least 18 years of age at the time of written informed consent
Exclusion
- Pregnancy, lactation, or any child-bearing potential
- Patients who are candidates for percutaneous transluminal coronary angioplasty (PTCA) or stenting
- Severe left ventricular dysfunction (ejection fraction \< 30%)
- Threatened proximal coronary occlusion or unstable angina
- Recent myocardial infarction (\< 1 month)
- Chronic renal failure (serum creatinine \> 130 µmol/L)
- Hepatic insufficiency (Child-Pugh Class C)
- Clinically significant valvular heart disease
- Personal history of neoplasia
- Abnormal serum prostate-specific antigen (PSA), bowel neoplasia screening questionnaire, or updated mammography report (if female) - any test not performed within the last 6 months will be conducted prior to confirmation of eligibility
- Family history of cancer (i.e. ≥ 2 first-degree relatives)
- History of diabetic retinopathy
- Latent herpes infection
- Schizophrenia
- Claustrophobia
Key Trial Info
Start Date :
November 1 2004
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 1 2007
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT00134433
Start Date
November 1 2004
End Date
October 1 2007
Last Update
June 21 2012
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Division of Cardiac Surgery, University of Ottawa Heart Institute
Ottawa, Ontario, Canada, K1Y 4W7