Status:
COMPLETED
Feasibility Study of Incorporating 18F-FDG-PET Imaging in Radiotherapy for Head and Neck Cancer
Lead Sponsor:
University Hospital, Ghent
Collaborating Sponsors:
Belgian Federation Against Cancer
Conditions:
Head and Neck Neoplasms
Eligibility:
All Genders
18+ years
Phase:
PHASE1
Brief Summary
The purpose of this trial is to study fluorodeoxyglucose-positron emission tomography (FDG-PET)-based dose escalation using intensity modulated radiation therapy (IMRT).
Detailed Description
The dose escalation, based on the FDG-PET signal, is incorporated in the first ten fractions of the radiotherapeutic treatment. The total amount of fractions is 32, equal to a standard radiotherapeuti...
Eligibility Criteria
Inclusion
- Patients with a proven histological squamous cell carcinoma of the larynx (only T3-4 NO or Tany N+), hypopharynx, oropharynx
- Patients who did not undergo surgery for the primary tumor location
- Patients with a Karnofsky performance score of 70% or more
- Written informed consent for participation in this trial
Exclusion
- Other malignancy except for non-melanoma skin cancer
- Prior irradiation to the head and neck region
Key Trial Info
Start Date :
September 1 2003
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
August 1 2015
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT00135161
Start Date
September 1 2003
End Date
August 1 2015
Last Update
December 8 2022
Active Locations (1)
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1
University Hospital Ghent
Ghent, Belgium, 9000