Status:
COMPLETED
Effectiveness of Bupropion Combined With Behavioral Therapy for Treating Methamphetamine Dependence - 2
Lead Sponsor:
National Institute on Drug Abuse (NIDA)
Collaborating Sponsors:
University of California, Los Angeles
Conditions:
Methamphetamine
Eligibility:
All Genders
18-100 years
Phase:
PHASE2
Brief Summary
Methamphetamine is an addictive stimulant drug that strongly activates certain parts of the brain. The purpose of this study is to determine the effectiveness of bupropion in combination with behavior...
Detailed Description
Methamphetamine is a drug that causes excess amounts of the neurotransmitters dopamine and norepinephrine to be released into the brain. This overload produces unusual alertness and feelings of elatio...
Eligibility Criteria
Inclusion
- Meets DSM-IV criteria for methamphetamine dependence
- Females must use an effective method of contraception
Exclusion
- History of or current medical condition that might interfere with safe participation, such as active tuberculosis, unstable heart or liver disease, unstable diabetes, symptomatic AIDS (non-symptomatic HIV infection is not an exclusion), or greater than 8 times the upper limit of normal in liver screening function tests (SGOT or SGPT)
- Current neurological disorder (e.g., organic brain disease, dementia)
- Major psychiatric disorder unrelated to substance abuse, such as schizophrenia or bipolar disorder (assessed by the SCID and a medical history)
- Suicide attempt within the month prior to enrollment and/or currently suicidal (assessed by the SCID and the BDI II)
- Currently on prescription medication that might interact with the study drug
- Currently dependent on cocaine, opiates, alcohol, or benzodiazepines, as defined by DSM-IV-TR criteria
- History of alcohol dependence within past three years
- History of seizure disorders
- History of anorexia or bulimia
- Current hypertension uncontrolled by medication
- History of sensitivity to bupropion
- Pregnant or breastfeeding
Key Trial Info
Start Date :
October 1 2005
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 1 2007
Estimated Enrollment :
73 Patients enrolled
Trial Details
Trial ID
NCT00135785
Start Date
October 1 2005
End Date
May 1 2007
Last Update
January 12 2017
Active Locations (2)
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1
UCLA Medical Center
Los Angeles, California, United States, 90024
2
Rancho Cucamonga Clinic
Rancho Cucamonga, California, United States, 91730