Status:
COMPLETED
Movement-Related Brain Networks Involved in Hand Dystonia
Lead Sponsor:
National Institute of Neurological Disorders and Stroke (NINDS)
Conditions:
Movement Disorder
Focal Dystonia
Eligibility:
All Genders
18+ years
Brief Summary
This study will use various methods to measure the activity of the motor cortex (the part of the brain that controls movements) in order to learn more about focal hand dystonia. Patients with dystonia...
Detailed Description
Objective Dystonia is a disabling movement disorder that manifests with sustained co-contraction of agonist and antagonist muscles, giving rise to abnormal twisted postures and overflow of muscle act...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- Normal subjects: Healthy volunteers ages 18 and older who consent to participate in the study
- Patients ages 18 and older diagnosed with focal hand dystonia unilateral focal hand dystonia who consent to participate in the study
- EXCLUSION CRITERIA:
- Normal subjects: abnormal neurologic exam or history of previous neurological disease that might affect the functioning of the hands
- Dystonia patients: presence of a second neurologic disease or condition that might affect the functioning of the hands; abnormal neurologic findings on exam not related to the focal hand dystonia that might affect the functioning of the hands; the use of Botulinum toxin within 3 months prior to study participation
- For MRI studies, patients with metallic implants will be excluded to avoid potential risks from this procedure
- For MRI studies, women who are pregnant are excluded from this part of the protocol. All women of childbearing potential will have a pregnancy test performed prior to MRI studies, which must be negative, before proceeding.
Exclusion
Key Trial Info
Start Date :
August 25 2005
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
April 27 2018
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT00137384
Start Date
August 25 2005
End Date
April 27 2018
Last Update
May 1 2018
Active Locations (1)
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1
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States, 20892